Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Hypromellose (HPMC) is a water-soluble hydrophilic, non-ionic cellulose ether.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
10 g | In stock | $ 39.00 |
Description | Hypromellose (HPMC) is a water-soluble hydrophilic, non-ionic cellulose ether. |
In vitro | Hypromellose (hydroxypropylmethylcellulose) is a long-established component of sustained-release pharmaceutical formulations. In matrix tablets, this polymer rapidly absorbs water, forming a viscous gel barrier that encapsulates the tablet. The modulation of drug release rates by hypromellose is governed by several factors, including the water diffusion rate into the polymer, the kinetics of hypromellose hydration and subsequent gelation, the viscosity of the gel produced, and the erosion rate of the gel layer [2]. This mechanism enables hypromellose to facilitate a controlled drug release, extending the drug's therapeutic efficacy [1]. |
In vivo | Punctal occlusion using hypromellose 2% is a low-cost and safe additional treatment for dry eye. Fluorescein and rose bengal staining tests show that there was a significant reduction in signs after occlusion using hypromellose [3]. Hypromellose is effective in improving blood glucose metabolism and suppressing oxidative stress in mice fed with a high-fat diet. The antihyperglycemic and antioxidative effects of hypromellose could be partly attributed to the regulation of hepatic glucose-regulating enzyme activities and activation of the hepatic and erythrocyte antioxidant enzymes [4]. |
Synonyms | Celacol HPM 5000, HPMC, (Hydroxypropyl)methyl cellulose |
Molecular Weight | 1261.44 |
Formula | C56H108O30 |
CAS No. | 9004-65-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 22 mg/mL, Sonication is recommended.
H2O: 9 mg/mL, Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Hypromellose 9004-65-3 Others Celacol HPM 5000 Celacol HPM5000 HPMC inhibit (Hydroxypropyl)methyl cellulose Inhibitor Celacol HPM-5000 inhibitor