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Hydroxybupropion

Catalog No. T11588 CAS 92264-81-8

Synonyms: Hydroxybupropione, 6-Hydroxybupropion, Hydroxybupropion, (+/-)-

Hydroxybupropion is the major active metabolite of Bupropion and an antagonist of nACh receptor. Hydroxybupropion inhibits <a href="/target/Norepinephrine" style="display: inline; color: #c13a36">Norepinephrine</a> uptake (IC50 = 1.7 μM).

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Hydroxybupropion, CAS 92264-81-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 147.00
2 mg	In stock	$ 217.00
5 mg	In stock	$ 331.00
10 mg	In stock	$ 519.00
25 mg	In stock	$ 868.00
50 mg	In stock	$ 1,298.00
100 mg	In stock	$ 1,938.00
200 mg	In stock	$ 2,925.00

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Purity: 98.61%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Hydroxybupropion is the major active metabolite of Bupropion and an antagonist of nACh receptor. Hydroxybupropion inhibits norepinephrine uptake (IC50 = 1.7 μM).
Targets&IC50	Norepinephrine uptake:1.7 μM
In vitro	Hydroxybupropion shows stronger antitetrabenazine activity and has a lower LD50 value than the erythro- and threo- metabolites. Hydroxybupropion inhibits norepinephrine and dopamine uptake, antagonizes nicotine, and shows antidepressant effects in rodents[1].

Synonyms	Hydroxybupropione, 6-Hydroxybupropion, Hydroxybupropion, (+/-)-
Molecular Weight	255.74
Formula	C13H18ClNO2
CAS No.	92264-81-8

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 90mg/mL (351.9mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Damaj MI, et al. Enantioselective effects of hydroxy metabolites of bupropion on behavior and on function of monoamine transporters and nicotinic receptors. Mol Pharmacol. 2004 Sep;66(3):675-82.

Related compound libraries

This product is contained In the following compound libraries：

Bioactive Compounds Library Max Neurotransmitter Receptor Compound Library Bioactive Compound Library Antidepressant Compound Library Inhibitor Library

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Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Hydroxybupropion 92264-81-8 Neuroscience AChR Norepinephrine Hydroxybupropione 6-Hydroxybupropion Hydroxybupropion, (+/-)- Inhibitor inhibitor inhibit

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