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Hydroxybupropion
🥰Excellent
Catalog No. T11588Cas No. 92264-81-8
Alias Hydroxybupropione, Hydroxybupropion, (+/-)-, 6-Hydroxybupropion
Hydroxybupropion is the major active metabolite of Bupropion and an antagonist of nACh receptor. Hydroxybupropion inhibits norepinephrine uptake (IC50 = 1.7 μM).
Hydroxybupropion
🥰Excellent
Purity: 98.61%
Catalog No. T11588Alias Hydroxybupropione, Hydroxybupropion, (+/-)-, 6-HydroxybupropionCas No. 92264-81-8
Hydroxybupropion is the major active metabolite of Bupropion and an antagonist of nACh receptor. Hydroxybupropion inhibits norepinephrine uptake (IC50 = 1.7 μM).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $119 | In Stock | |
| 2 mg | $176 | In Stock | |
| 5 mg | $297 | In Stock | |
| 10 mg | $463 | In Stock | |
| 25 mg | $743 | In Stock | |
| 50 mg | $987 | In Stock | |
| 100 mg | $1,370 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $297 | In Stock |
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CitedSelect Batch
Purity:98.61%
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.Product Introduction
Bioactivity
Chemical Properties
| Description | Hydroxybupropion is the major active metabolite of Bupropion and an antagonist of nACh receptor. Hydroxybupropion inhibits norepinephrine uptake (IC50 = 1.7 μM). |
| Targets&IC50 | Norepinephrine uptake:1.7 μM |
| In vitro | Hydroxybupropion shows stronger antitetrabenazine activity and has a lower LD50 value than the erythro- and threo- metabolites. Hydroxybupropion inhibits norepinephrine and dopamine uptake, antagonizes nicotine, and shows antidepressant effects in rodents[1]. |
| Alias | Hydroxybupropione, Hydroxybupropion, (+/-)-, 6-Hydroxybupropion |
| Molecular Weight | 255.74 |
| Formula | C13H18ClNO2 |
| Cas No. | 92264-81-8 |
| Smiles | C(C(NC(CO)(C)C)C)(=O)C1=CC(Cl)=CC=C1 |
| Relative Density. | 1.15 g/cm3 |
Storage & Solubility Information
| Storage | keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 90 mg/mL (351.9 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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