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Gitogenin

Catalog No. T3S0860   CAS 511-96-6

1. Gitogenin, tigogenin, and solasodine are novel selective inhibitors of UGT1A4, and do not inhibit the activities of major human CYP isoforms. 2. Gitogenin and (25S)-5α-furastan-3β, 22, 26-triol are the inhibitors of enzyme α-glucosidase with IC50 values of 37.2±0.18 and 33.5±0.22 uM, respectively.3. Gitogenin shows moderate stimulation of release activity on growth hormone from rat pituitary cells.

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Gitogenin Chemical Structure
Gitogenin, CAS 511-96-6
Pack Size Availability Price/USD Quantity
1 mg In stock $ 90.00
5 mg In stock $ 193.00
10 mg In stock $ 333.00
25 mg In stock $ 565.00
50 mg In stock $ 812.00
100 mg In stock $ 1,130.00
1 mL * 10 mM (in DMSO) In stock $ 228.00
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Purity: 99.73%
Purity: 99.73%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description 1. Gitogenin, tigogenin, and solasodine are novel selective inhibitors of UGT1A4, and do not inhibit the activities of major human CYP isoforms. 2. Gitogenin and (25S)-5α-furastan-3β, 22, 26-triol are the inhibitors of enzyme α-glucosidase with IC50 values of 37.2±0.18 and 33.5±0.22 uM, respectively.3. Gitogenin shows moderate stimulation of release activity on growth hormone from rat pituitary cells.
Targets&IC50 α-glucosidase:IC50 : 37.2 μM, UDP-glucuronosyltransferase 1A4:0.69 µM (IC50)
Source
Molecular Weight 432.64
Formula C27H44O4
CAS No. 511-96-6

Storage

store at low temperture,keep away from direct sunlight,store under nitrogen

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 4.33 mg/mL (10 mM), Sonification is recommended

Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.: Soluble

TargetMolReferences and Literature

1. Shim S , Lee E , Kim J , et al. Rat Growth-Hormone Release Stimulators from Fenugreek Seeds[J]. Chemistry & Biodiversity, 2008, 5(9):1753-1761.

Related compound libraries

This product is contained In the following compound libraries:
Natural Product Library Traditional Mongolian Medicine Compound Library Selected Plant-Sourced Compound Library RO5 Drug-like Natural Product Library NO PAINS Compound Library Natural Product Library for HTS Bioactive Compounds Library Max Traditional Chinese Medicine Monomer Library Bioactive Compound Library Anti-COVID-19 Traditional Chinese Medicine Compound Library

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Keywords

Gitogenin 511-96-6 Metabolism UGT Glucosidase Inhibitor inhibit inhibitor

 

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