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Gastrodin

Catalog No. T2999   CAS 62499-27-8
Synonyms: Gastrodine

Gastrodin (Gastrodine), an anti-inflammatory polyphenol, is extracted from Chinese natural herbal Gastrodia elata Blume. and benefits neurodegenerative diseases.

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Gastrodin Chemical Structure
Gastrodin, CAS 62499-27-8
Pack Size Availability Price/USD Quantity
50 mg In stock $ 50.00
1 mL * 10 mM (in DMSO) In stock $ 50.00
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Purity: 100%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Gastrodin (Gastrodine), an anti-inflammatory polyphenol, is extracted from Chinese natural herbal Gastrodia elata Blume. and benefits neurodegenerative diseases.
In vitro In mice, the LD50 of Gastrodin is greater than 1000 mg/kg (i.v.). In rats, Gastrodin at a dose of 5 mg/kg is effective in alleviating memory deficits induced by cycloheximide and apomorphine but is ineffective against scopolamine-induced acquisition impairments. Therefore, Gastrodin enhances memory consolidation and retrieval but does not facilitate memory acquisition.
In vivo In microglial cells stimulated by lipopolysaccharide, Gastrodin at concentrations of 30, 40, and 60 mM inhibits the NF-κB signaling pathway and phosphorylation of MAPKs, significantly reducing the levels of neurotoxic inflammatory mediators and cytokines. Furthermore, in H9c2 cardiomyocytes, Gastrodin upregulates the PI3-K/Akt signaling pathway, consequently inhibiting the activation of NF-κB and MAPKs.
Source
Synonyms Gastrodine
Molecular Weight 286.28
Formula C13H18O7
CAS No. 62499-27-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 55 mg/mL (192.12 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

TargetMolReferences and Literature

1. Dai JN, et al. PLoS One, 2011, 6(7), e21891. 2. Yang P, et al. Biochem Pharmacol, 2013, 85(8), 1124-1133. 3. Hsieh MT, et al. J Ethnopharmacol, 1997, 56(1), 45-54.

Related compound libraries

This product is contained In the following compound libraries:
Microbial Natural Product Library Miao medicine Compound Library Natural Product Library for HTS Drug Repurposing Compound Library Saccharide and Glycoside Natural Product Library Natural Product Library Traditional Chinese Medicine Monomer Library Anti-Aging Compound Library Anti-Fibrosis Compound Library Food as Medicine Compound Library

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Keywords

Gastrodin 62499-27-8 Others Gastrodine Inhibitor inhibit inhibitor

 

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