Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Gastrodin (Gastrodine), an anti-inflammatory polyphenol, is extracted from Chinese natural herbal Gastrodia elata Blume. and benefits neurodegenerative diseases.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
50 mg | In stock | $ 50.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 50.00 |
Description | Gastrodin (Gastrodine), an anti-inflammatory polyphenol, is extracted from Chinese natural herbal Gastrodia elata Blume. and benefits neurodegenerative diseases. |
In vitro | In mice, the LD50 of Gastrodin is greater than 1000 mg/kg (i.v.). In rats, Gastrodin at a dose of 5 mg/kg is effective in alleviating memory deficits induced by cycloheximide and apomorphine but is ineffective against scopolamine-induced acquisition impairments. Therefore, Gastrodin enhances memory consolidation and retrieval but does not facilitate memory acquisition. |
In vivo | In microglial cells stimulated by lipopolysaccharide, Gastrodin at concentrations of 30, 40, and 60 mM inhibits the NF-κB signaling pathway and phosphorylation of MAPKs, significantly reducing the levels of neurotoxic inflammatory mediators and cytokines. Furthermore, in H9c2 cardiomyocytes, Gastrodin upregulates the PI3-K/Akt signaling pathway, consequently inhibiting the activation of NF-κB and MAPKs. |
Source |
Synonyms | Gastrodine |
Molecular Weight | 286.28 |
Formula | C13H18O7 |
CAS No. | 62499-27-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 50 mg/mL (174.65 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Gastrodin 62499-27-8 Others Gastrodine Inhibitor inhibit inhibitor