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GX-674

Catalog No. T22829 CAS 1432913-36-4

GX-674 is a highly potent and selective voltage-gated sodium channel 1.7 (Nav1.7) antagonist with an IC50 value of 0.1 nM measured at -40 mV for the study of inflammatory and neuropathic pain.

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GX-674, CAS 1432913-36-4

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 1,520.00
50 mg	6-8 weeks	$ 1,980.00
100 mg	6-8 weeks	$ 2,500.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

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Biological Description

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Description	GX-674 is a highly potent and selective voltage-gated sodium channel 1.7 (Nav1.7) antagonist with an IC50 value of 0.1 nM measured at -40 mV for the study of inflammatory and neuropathic pain.
Targets&IC50	Nav1.7:0.1 nM
In vitro	In HEK293 cells, the patch-clamp analysis was performed for human Nav channels. GX-674 shows a potent inhibition effect on Nav.1.7 (IC50= 0.1nM). GX-674 also displays substantial selectivity on different Nav subtypes. It shows much higher inhibitory effects on Nav 1.7 over other Nav isoforms, such as 100000 times more potent for Nav1.7 than for Nav 1.5. GX-74 is also reported to bind to a high-affinity, isoform-selective, and extracellularly accessible site on VSD4.[1]

Molecular Weight	534.95
Formula	C21H13ClF2N6O3S2
CAS No.	1432913-36-4

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: Soluble

References and Literature

1. Ahuja S, et al. Structural basis of Nav1.7 inhibition by an isoform-selective small-molecule antagonist. Science. 2015 Dec 18;350(6267):aac5464.

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Keywords

GX-674 1432913-36-4 Membrane transporter/Ion channel Sodium Channel GX 674 GX674 inhibitor inhibit

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