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Home > Chromatin/Epigenetic > Histone Demethylase > GSK J1

GSK J1

Catalog No. T6847    CAS 1373422-53-7   

GSK-J1 is a highly potent H3K27 histone demethylase inhibitor with IC50 of 28 nM and 53 nM in cell-free assays for JMJD3 (KDM6B) and UTX (KDM6A), respectively, >10-fold selectivity over other tested demethylases.

Pack Size Availability Price/USD Quantity
5 mg In stock 50.00
10 mg In stock 86.00
25 mg In stock 180.00
50 mg In stock 320.00
100 mg In stock 520.00
200 mg In stock 859.00
1 mL * 10 mM (in DMSO) In stock 50.00
Bulk Size: Please Quote for Discount Please Quote for Bulk Size
Biological Activity:

Product Description:

GSK-J1 is a highly potent H3K27 histone demethylase inhibitor with IC50 of 28 nM and 53 nM in cell-free assays for JMJD3 (KDM6B) and UTX (KDM6A), respectively, >10-fold selectivity over other tested demethylases.

Receptor:

JMJD3; UTX (KDM6A); JMJD3 (KDM6B);

Chemical Information:
Molecular Weight 389.45
Formula C22H23N5O2
CAS Number 1373422-53-7
Solubility

DMSO: 38.9 mg/mL (100 mM)

Ethanol: 38.9 mg/mL (100 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )
Storage store at -80°C
Remark For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ℃ for several month.