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GNE-140 racemate

Catalog No. T13450L CAS 1802977-61-2

Synonyms: GNE-140 (racemate)

GNE-140 is a potent inhibitor of lactate dehydrogenase A (LDHA). GNE-140 is a racemate mixture of (R)-GNE-140 and (S)-GNE-140.

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GNE-140 racemate, CAS 1802977-61-2

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	GNE-140 is a potent inhibitor of lactate dehydrogenase A (LDHA). GNE-140 is a racemate mixture of (R)-GNE-140 and (S)-GNE-140.
In vitro	Lactate dehydrogenase A (LDHA) is a key glycolytic enzyme and is also a hallmark of aggressive cancers. Which believed to be the major enzyme responsible for the pyruvate-to-lactate conversion. Because of increased glycolysis, increased glucose consumption distinguishes cancer cells from normal cells and is known as the 'Warburg effect”[1].

Synonyms	GNE-140 (racemate)
Molecular Weight	499.04
Formula	C25H23ClN2O3S2
CAS No.	1802977-61-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 34 mg/mL (68.13 mM)

References and Literature

1. Ždralević M, et al. Double genetic disruption of lactate dehydrogenases A and B is required to ablate the "Warburg effect" restricting tumor growth to oxidative metabolism. J Biol Chem. 2018 Oct 12;293(41):15947-15961. 2. Purkey HE, et al. Cell Active Hydroxylactam Inhibitors of Human Lactate Dehydrogenase with Oral Bioavailability in Mice. ACS Med Chem Lett. 2016 Aug 26;7(10):896-901.

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Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

GNE-140 racemate 1802977-61-2 Others GNE-140 (racemate) GNE 140 GNE140 racemate GNE140 GNE-140 racemate GNE 140 racemate inhibitor inhibit

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