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GJ103 sodium salt

Catalog No. T4251 CAS 1459687-96-7

GJ103 sodium salt is an active analog of GJ072, a read-through compound. It has been shown to reduce the surface tension of aqueous solutions, which makes it easier for molecules to move through the solution. It has also been shown to reduce the viscosity of aqueous solutions, which makes it easier for molecules to move through the solution. Additionally, it has been shown to reduce the pH of aqueous solutions, which can have a variety of effects on the biochemical and physiological processes of living organisms.

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GJ103 sodium salt, CAS 1459687-96-7

Pack Size	Availability	Price/USD
2 mg	In stock	$ 42.00
5 mg	In stock	$ 78.00
10 mg	In stock	$ 126.00
25 mg	In stock	$ 256.00
50 mg	In stock	$ 442.00
100 mg	In stock	$ 481.00
1 mL * 10 mM (in DMSO)	In stock	$ 72.00

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Purity: 99.88%

Purity: 99.75%

Purity: 99.72%

Purity: 99.63%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	GJ103 sodium salt is an active analog of GJ072, a read-through compound. It has been shown to reduce the surface tension of aqueous solutions, which makes it easier for molecules to move through the solution. It has also been shown to reduce the viscosity of aqueous solutions, which makes it easier for molecules to move through the solution. Additionally, it has been shown to reduce the pH of aqueous solutions, which can have a variety of effects on the biochemical and physiological processes of living organisms.
In vitro	GJ072 induces ATM kinase on both TGA and TAG stop codons and restored ATMpSer1981 autophosphorylation and SMC1pSer966 transphosphorylation as measured by FACS. GJ072 is active in A-T cells with a homozygous TAA mutation. GJ072 is able to induce detectable full-length ATM protein in treated A-T cells. Early structure-activity relationship studies generates eight active analogs of GJ072. Some GJ072 analogs (e.g., GJ103, GJ106, GJ109, and GJ111) consistently demonstrates their activities in all three PTCs by both FCATMpSer1981 and IRIF assays. GJ071 and GJ072 and some of their analogs (such as GJ103) have similar read-through activity as RTC13 or RTC14, but are more tolerable than RTC13 and RTC14 to A-T cells. GJ103 does not show obvious cytotoxicity in A-T cells at concentration as high as 300 μM.
In vivo	GJ103 sodium salt is water soluble, which will enable us to evaluate its in vivo activity by systematic administration.
Cell Research	Cell proliferation assay is used to measure cytotoxicity. Cells are seeded into a flat-bottom 96-well plate, including control wells containing complete growth medium alone as blank absorbance readings. After RTC treatment (GJ103), activated-XTT Solution is added into each well, and the cells are returned to the cell culture incubator for 12-14 hours. The absorbance is measured at 480 nM with relevant 630 nM to assess nonspecific readings.

Molecular Weight	364.36
Formula	C16H13N4NaO3S
CAS No.	1459687-96-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: Soluble

DMSO: 50 mg/mL (137.23 mM)

References and Literature

1. Du L, et al. A new series of small molecular weight compounds induce read through of all three types of nonsense mutations in the ATM gene. Mol Ther. 2013 Sep;21(9):1653-60.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Prostate Cancer Compound Library Anti-Ovarian Cancer Compound Library Kinase Inhibitor Library Neural Regeneration Compound Library Anti-Colorectal Cancer Compound Library Bioactive Compound Library Metabolism Compound Library Neuronal Differentiation Compound Library Bioactive Compounds Library Max Oxidation-Reduction Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Keywords

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