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Formoterol fumarate

Catalog No. T6505 CAS 43229-80-7

Synonyms: Formoterol Hemifumarate, NSC 299587, Eformoterol Hemifumarate, CGP 25827A, Eformoterol, YM 08316

Formoterol fumarate (Eformoterol Hemifumarate), an effective, specific and long-acting β2-adrenoceptor agonist, is utilized in the treatment of chronic obstructive pulmonary disease(COPD) and asthma.

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Formoterol fumarate, CAS 43229-80-7

Pack Size	Availability	Price/USD
5 mg	In stock	$ 41.00
10 mg	In stock	$ 64.00
25 mg	In stock	$ 143.00
50 mg	In stock	$ 268.00
100 mg	In stock	$ 405.00
200 mg	In stock	$ 585.00
1 mL * 10 mM (in DMSO)	In stock	$ 45.00

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Purity: 100%

Purity: 99.86%

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Description	Formoterol fumarate (Eformoterol Hemifumarate), an effective, specific and long-acting β2-adrenoceptor agonist, is utilized in the treatment of chronic obstructive pulmonary disease(COPD) and asthma.
In vitro	In guinea pig lungs, Formoterol at a concentration of 100 mg/mL inhibits Platelet-Activating Factor (PAF)-induced eosinophil aggregation and suppresses Porcine Pancreatic Elastase (PPE) activity for 2-4 hours. In conscious guinea pigs, Formoterol dose-dependently inhibits histamine-induced plasma protein leakage and bronchoconstriction. Significant inhibition of histamine-induced effects was observed at doses of 10 mg/mL and 100 mg/mL. Additionally, a higher concentration of Formoterol is required to inhibit neutrophil aggregation (induced by Lipopolysaccharides) compared to its ability to suppress granulocyte-independent PPE (induced by histamine).
In vivo	Formoterol is a high-affinity, selective β2-adrenergic receptor agonist that effectively relaxes airway smooth muscles. Similar to salbutamol and salmeterol, it relaxes guinea pig trachea and human bronchi in vitro in a concentration-dependent manner and inhibits the release of antigen-induced inflammatory mediators in human lung slices.

Synonyms	Formoterol Hemifumarate, NSC 299587, Eformoterol Hemifumarate, CGP 25827A, Eformoterol, YM 08316
Molecular Weight	402.4
Formula	C19H24N2O4·1/2C4H4O4
CAS No.	43229-80-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 74 mg/mL (183.9 mM)

References and Literature

1. Anderson GP, et al. Life Sci, 1993, 52(26), 2145-2160. 2. Nials AT, et al. Eur J Pharmacol, 1994, 251(2-3), 127-135. 3. Whelan CJ, et al. Br J Pharmacol, 1993, 110(2), 613-618.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Approved Drug Library Drug Repurposing Compound Library Anti-Cancer Clinical Compound Library Membrane Protein-targeted Compound Library GPCR Compound Library EMA Approved Drug Library Anti-Cancer Drug Library Anti-Neurodegenerative Disease Compound Library Clinical Compound Library Anti-Alzheimer's Disease Compound Library

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Keywords

Formoterol fumarate 43229-80-7 GPCR/G Protein Neuroscience Adrenergic Receptor inhibit YM08316 Formoterol Hemifumarate NSC299587 Beta Receptor Inhibitor NSC-299587 NSC 299587 YM-08316 Formoterol Fumarate Eformoterol Hemifumarate Formoterol CGP 25827A Eformoterol YM 08316 (±)Formoterol inhibitor

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