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Flumethasone

Catalog No. T1124   CAS 2135-17-3
Synonyms: Flumetasone, RS-2177, NSC-54702

Flumethasone (RS-2177) is a glucocorticoid receptor agonist, with anti-inflammatory, antipruritic and vasoconstrictive properties.

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Flumethasone Chemical Structure
Flumethasone, CAS 2135-17-3
Pack Size Availability Price/USD Quantity
50 mg In stock $ 53.00
100 mg In stock $ 81.00
1 mL * 10 mM (in DMSO) In stock $ 50.00
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Purity: 99.91%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Flumethasone (RS-2177) is a glucocorticoid receptor agonist, with anti-inflammatory, antipruritic and vasoconstrictive properties.
Kinase Assay Topoisomerase I Cleavable Complex Assay: Topoisomerase I is isolated from calf thymus and is devoid of topoisomerase II. All reactions are carried out in 10 mL volumes of reaction buffer (50 mM Tris-HCl, pH 7.5, 100 mM KCl, 0.5 mM EDTA, and 30 pg/mL BSA) in microtiter plates. Camptothecin is dissolved in DMSO at 10 mg/mL and serially diluted in 96-well microtiter plates to which the 32P end-labeled pBR322 DNA and topoisomerase enzyme are added. The reaction mixture is incubated at room temperature for 30 min and then the reaction stopped by adding 2 mL of a mixture of sodium dodecyl sulfate and proteinase K (1.6% and 0.14 mg/mL final concentrations, respectively). The plates are heated at 50 °C for 30 min, 10 mL of standard stop mixture containing 0.45 N NaOH is added in order to generate single-stranded DNA, and the samples are electrophoresed in 1.5% agarose gels in TBE buffer. Gels are blotted on nitrocellulose paper, dried, and exposed to X-ray film. The units of cleavage are calculated from the autoradiographs and plotted against the log drug concentration. The IC50 values are then obtaine
Synonyms Flumetasone, RS-2177, NSC-54702
Molecular Weight 410.45
Formula C22H28F2O5
CAS No. 2135-17-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 76 mg/mL (185.2 mM)

Ethanol: 6 mg/mL (14.61 mM)

TargetMolReferences and Literature

1. Sternbauer K, et al. Zentralbl Veterinarmed A, 1998, 45(6-7), 441-443. 2. Sustronck B, et al. Zentralbl Veterinarmed A, 1997, 44(3), 179-187. 3. Shpigel NY, et al. J Am Vet Med Assoc, 1996, 208(10), 1702-1704. 4. Van Den Hauwe O, et al. J Agric Food Chem, 2003, 51(1), 326-330.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Drug Library Anti-Cancer Approved Drug Library FDA-Approved Drug Library Fluorochemical Library Approved Drug Library Bioactive Compound Library FDA-Approved & Pharmacopeia Drug Library Endocrinology-Hormone Compound Library Drug Repurposing Compound Library Anti-Metabolism Disease Compound Library

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Keywords

Flumethasone 2135-17-3 Endocrinology/Hormones Glucocorticoid Receptor RS2177 inhibit NSC54702 Inhibitor RS 2177 Flumetasone NSC 54702 RS-2177 NSC-54702 inhibitor

 

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