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Fiacitabine

Catalog No. T15280 CAS 69123-90-6

Synonyms: FOAC, FIAC, NSC 382097

Fiacitabine (NSC-382097) is a selective inhibitor of DNA replication of the herpes simplex virus(HSV) (IC50: 2.5 nM and 12.6 nM for HSV1 and HSV2, respectively).

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Fiacitabine, CAS 69123-90-6

Pack Size	Availability	Price/USD
1 mg	In stock	$ 163.00
5 mg	In stock	$ 347.00
10 mg	In stock	$ 497.00
25 mg	In stock	$ 796.00
50 mg	In stock	$ 1,080.00
100 mg	In stock	$ 1,450.00
500 mg	In stock	$ 2,920.00
1 mL * 10 mM (in DMSO)	In stock	$ 382.00

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Purity: 99.21%

Biological Description

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Storage & Solubility Information

Description	Fiacitabine (NSC-382097) is a selective inhibitor of DNA replication of the herpes simplex virus(HSV) (IC50: 2.5 nM and 12.6 nM for HSV1 and HSV2, respectively).
Targets&IC50	HSV1:2.5 nM, HSV2:12.6 nM
In vitro	FIAC was active at much lower concentrations than arabinosylcytosine, iododeoxyuridine, and arabinosyladenine. It was slightly more active against herpes simplex virus type 1 than acycloguanosine and slightly more toxic to normal cells. FIAC was about 8,000 times more active against the replication of wild-type herpes simplex virus type 1 than against a mutant strain lacking the expression of a virus-specified thymidine kinase. HSV FIAC suppressed by 90% the replication of various strains of herpes simplex virus types 1 and 2 at concentrations of 0.0025 to 0.0126 microM. Cytotoxicity was minimal, as determined by trypan blue dye exclusion with norman Vero, WI-38, and NC-37 cell proliferation; the 50% inhibitory dose was 4 to 10 microM in a 4-day assay [2].

Synonyms	FOAC, FIAC, NSC 382097
Molecular Weight	371.1
Formula	C9H11FIN3O4
CAS No.	69123-90-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 35 mg/mL (94.31 mM)

References and Literature

1. Allaudeen HS, et al. Selective inhibition of DNA replication in herpes simplex virus infected cells by 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-iodocytosine. J Biol Chem. 1982 Oct 25;257(20):11879-82. 2. Lopez C, et al. 2'-fluoro-5-iodo-aracytosine, a potent and selective anti-herpesvirus agent. Antimicrob Agents Chemother. 1980 May;17(5):803-6.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Drug Repurposing Compound Library Anti-Viral Compound Library Clinical Compound Library Human Metabolite Library Bioactive Compound Library NO PAINS Compound Library Anti-Infection Compound Library Bioactive Compounds Library Max

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Fiacitabine 69123-90-6 Microbiology/Virology HSV NSC382097 NSC-382097 Herpes simplex virus FOAC inhibit FIAC NSC 382097 Inhibitor inhibitor

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