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FT113

Catalog No. T7947 CAS 1630808-89-7

FT113 is a novel potent inhibitor of fatty acid synthase (fasn, IC50 : 213 nM),and exhibits anti-cancer activity

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FT113, CAS 1630808-89-7

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	FT113 is a novel potent inhibitor of fatty acid synthase (fasn, IC50 : 213 nM),and exhibits anti-cancer activity
Targets&IC50	fas:213 nM
In vivo	FT113, a compound with potent biochemical and cellular activity, which translated into excellent activity in in vivo models.Caused 32 % and 50% tumor growth inhibition at 25 and 50 mg/kg, respectively in mice.
Animal Research	Athymic nude mice bearing MV-411 cells. Dosage:5, 25, or 50 mg/kg, twice daily for 16 days

Molecular Weight	409.417
Formula	C22H20FN3O4
CAS No.	1630808-89-7

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 62.5 mg/mL (152.66 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Martin MW, et al. Discovery and optimization of novel piperazines as potent inhibitors of fatty acid synthase (FASN). Bioorg Med Chem Lett. 2019 Apr 15;29(8):1001-1006.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Anti-Cancer Metabolism Compound Library Lipid Metabolism Compound Library Inhibitor Library Anti-Metabolism Disease Compound Library Anti-Cancer Active Compound Library Bioactive Compound Library

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

FT113 1630808-89-7 代谢 Fatty Acid Synthase FT 113 Fatty Acid Synthase (FASN) Inhibitor FT-113 inhibit inhibitor

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