Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Erastin2 is a ferroptosis inducer and an inhibitor of the system xc- cystine/glutamate transporter.[1] [2] It inhibits glutamate release in CCF-STTG1 cells (IC50 = 0.0035 µM).[2] It induces cell death in HAP1 cells when used at a concentration of 5 µM, an effect that can be blocked by the ferroptosis inhibitor ferrostatin-1 or deferoxamine . [1] Erastin2 also induces ferroptotic cell death in HT-1080 cells (EC50 = 0.15 µM), an effect that can be blocked by the reducing agent β-mercaptoethanol (EC50 = <20 µM). [3] It increases lipid peroxidation in HT-1080 cells when used at a concentration of 1 µM.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | 5 days | $ 95.00 | |
5 mg | 5 days | $ 177.00 | |
50 mg | 6-8 weeks | $ 714.00 | |
100 mg | 6-8 weeks | $ 1,120.00 |
Description | Erastin2 is a ferroptosis inducer and an inhibitor of the system xc- cystine/glutamate transporter.[1] [2] It inhibits glutamate release in CCF-STTG1 cells (IC50 = 0.0035 µM).[2] It induces cell death in HAP1 cells when used at a concentration of 5 µM, an effect that can be blocked by the ferroptosis inhibitor ferrostatin-1 or deferoxamine . [1] Erastin2 also induces ferroptotic cell death in HT-1080 cells (EC50 = 0.15 µM), an effect that can be blocked by the reducing agent β-mercaptoethanol (EC50 = >20 µM). [3] It increases lipid peroxidation in HT-1080 cells when used at a concentration of 1 µM. |
Synonyms | Erastin2 |
Molecular Weight | 623.14 |
Formula | C36H35ClN4O4 |
CAS No. | 1695533-44-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMF: 10 mg/mL
DMSO: 1 mg/mL
You can also refer to dose conversion for different animals. More
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Erastin2 1695533-44-8 Erastin-2 inhibitor inhibit