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Endostatin (84-114)-NH2 (JKC367)

Catalog No. TP2245 CAS TP2245

Endostatin is a potent inhibitor of primary tumor growth and endothelial cell proliferation and migration. Recombinant endostatin potently inhibited angiogenesis, maintains metastases at a low level, and suppressed tumors, a reduction of over 150-fold. Endostatin showed no toxicity to mice, no evidence of drug resistance, and no regrowth of tumors.

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Endostatin (84-114)-NH2 (JKC367) Chemical Structure

Endostatin (84-114)-NH2 (JKC367), CAS TP2245

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1 mg	Inquiry	$ 78.00
5 mg	Inquiry	$ 226.00
10 mg	Inquiry	$ 376.00
25 mg	Inquiry	$ 524.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Endostatin is a potent inhibitor of primary tumor growth and endothelial cell proliferation and migration. Recombinant endostatin potently inhibited angiogenesis, maintains metastases at a low level, and suppressed tumors, a reduction of over 150-fold. Endostatin showed no toxicity to mice, no evidence of drug resistance, and no regrowth of tumors.
In vitro	Endostatin and TNP-470 treatments inhibited atherosclerosis by 85% and 70%, respectively. Either treatment significantly inhibited plaque growth, but the degree of inhibition by endostatin was less than that by TNP-470. Significant inhibition of plaque growth by endostatin or TNP-470 was seen even when the treatment was delayed until 32 weeks, although the degree of inhibition was smaller. Both endostatin and TNP-470 are reversible inhibitors of endothelial cell proliferation and appear to exert few effects on quiescent nonproliferating endothelium. Endostatin administered continuously into the peritoneal cavity by a mini-osmotic pump is 50% more effective in tumor suppression than the same dose administered once a day i.p. [1].
In vivo	Furthermore, we show that a 10-fold lower dose, when given continuously, will accomplish the same tumor suppression as a single dose given i.p daily. Finally, we show that only continuous dosing can achieve tumor regression with human soluble endostatin. Endostatin retains biological activity in the osmotic pump for at least 7 days. Importantly, the endostatin does not undergo any obvious proteolytic degradation within an i.p. implanted pump. Soluble recombinant mouse endostatin has shown efficacy against a human renal carcinoma in mice when given i.p as a single bolus dose of 10 –20 mg/kg/day. However, only 30% of the animals in the treated group demonstrated tumor regression [3].

Molecular Weight	3531.9
Formula	C161H236N48O43
CAS No.	TP2245

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keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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DMSO: ≥353.2mg/mL

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Keywords

Endostatin (84-114)-NH2 (JKC367) TP2245 Others Endostatin (84 114) NH2 (JKC367) Endostatin (84114)NH2 (JKC367) Endostatin (84-114)-NH-2 (JKC367) JKC367 Endostatin NH2 JKC-367 JKC 367 inhibitor inhibit

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