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Dihydrocyclosporin A

Catalog No. T31467 CAS 59865-15-5

Synonyms: Dihydrocyclosporin-A

Dihydrocyclosporin A (Dihydrocyclosporin-A) is closely related co-metabolite of cyclosporin A. Dihydrocyclosporin A significantly inhibits promastigotes and intracellular amastigotes.

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Dihydrocyclosporin A, CAS 59865-15-5

Pack Size	Availability	Price/USD
1 mg	In stock	$ 129.00
5 mg	In stock	$ 320.00
10 mg	In stock	$ 470.00
25 mg	In stock	$ 772.00
50 mg	In stock	$ 1,080.00
100 mg	In stock	$ 1,460.00
1 mL * 10 mM (in DMSO)	In stock	$ 784.00

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Purity: 99.50%

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Description	Dihydrocyclosporin A (Dihydrocyclosporin-A) is closely related co-metabolite of cyclosporin A. Dihydrocyclosporin A significantly inhibits promastigotes and intracellular amastigotes.
Targets&IC50	Intracellular amastigotes:4.84 μM(48 h,L. donovani), Intracellular amastigotes:5.23 μM(24 h,L. donovani), Promastigotes:12.14(48 h,L. donovani), Promastigotes:21.24 μM(24 h,L. donovani)
In vitro	Dihydrocyclosporin A was able to inhibit the proliferation of L. donovani promastigotes (IC50: 21.24 μM and 12.14 μM at 24 h and 48 h, respectively) and intracellular amastigotes (IC50: 5.23 μM and 4.84 μM at 24 and 48 h, respectively) in vitro. Dihydrocyclosporin A caused several alterations in the morphology and ultrastructure of L. donovani, especially in the mitochondria. However, Dihydrocyclosporin A showed high cytotoxicity towards cells of the mouse macrophage cell line RAW264.7, with CC50 values of 7.98 μM (24 h) and 6.65 μM (48 h).[2].

Synonyms	Dihydrocyclosporin-A
Molecular Weight	1204.63
Formula	C62H113N11O12
CAS No.	59865-15-5

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/mL (49.81 mM)

References and Literature

1. Sanglier JJ, et al. Isolation of (4R)-4-[(E)-2-butenyl]-4-methyl-L-threonine, the characteristic structural element of cyclosporins, from a blocked mutant of Tolypocladium inflatum. J Antibiot (Tokyo). 1990 Jun;43(6):707-14. 2. Zheng ZW, et al. Evaluation of in vitro antileishmanial efficacy of cyclosporin A and its non-immunosuppressive derivative, dihydrocyclosporin A. Parasit Vectors. 2020 Feb 21;13(1):94. 3. Chappell LH, et al. Dosage, timing, and route of administration of cyclosporin A and nonimmunosuppressive derivatives of dihydrocyclosporin A and cyclosporin C against Schistosoma mansoni in vivo and in vitro. 4. Chappell LH, et al. Dosage, timing, and route of administration of cyclosporin A and nonimmunosuppressive derivatives of dihydrocyclosporin A and cyclosporin C against Schistosoma mansoni in vivo and in vitro. Antimicrob Agents Chemother. 1987 Oct;31(10):1567-71.

Related compound libraries

This product is contained In the following compound libraries：

Microbial Natural Product Library Natural Product Library for HTS Rare Natural Product Library

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Keywords

Dihydrocyclosporin A 59865-15-5 Others Dihydrocyclosporin-A inhibitor inhibit

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