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Dexmedetomidine

Catalog No. T2524   CAS 113775-47-6

Dexmedetomidine is a Central alpha-2 Adrenergic Agonist. The mechanism of action of dexmedetomidine is as an Adrenergic alpha2-Agonist. The physiologic effect of dexmedetomidine is by means of General Anesthesia.

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Dexmedetomidine Chemical Structure
Dexmedetomidine, CAS 113775-47-6
Pack Size Availability Price/USD Quantity
25 mg In stock $ 39.00
50 mg In stock $ 64.00
100 mg In stock $ 97.00
200 mg In stock $ 155.00
500 mg In stock $ 262.00
1 mL * 10 mM (in DMSO) In stock $ 43.00
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Purity: 100%
Purity: 99.96%
Purity: 99%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Dexmedetomidine is a Central alpha-2 Adrenergic Agonist. The mechanism of action of dexmedetomidine is as an Adrenergic alpha2-Agonist. The physiologic effect of dexmedetomidine is by means of General Anesthesia.
Targets&IC50 α2 receptor:1.08 nM(Ki )
In vitro Dexmedetomidine has a relatively high ratio of α2/α1-activity (1620:1 as compared with 220:1 for clonidine) and, therefore, is considered a full agonist of the α2 receptor. This may result in more potent effects of sedation without unwanted cardiovascular effects from α1 receptor activation. The 2-h half-life of dexmedetomidine is nearly 4-fold shorter than that of clonidine, which increases the likelihood that a continuous infusion of dexmedetomidine might be useful for sedation. Dexmedetomidine also has minimum alveolar anesthetic concentration (MAC)-sparing properties, but its use as an anesthetic adjuvant has been complicated by persistent hypotension that has mandated IV fluid administration and vasopressor administration. In addition, its use in large doses is complicated by hypertension from α2 receptor-mediated vascular constriction.
Molecular Weight 200.28
Formula C13H16N2
CAS No. 113775-47-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 40 mg/mL (199.72 mM)

TargetMolReferences and Literature

1. Virtanen R, et al. Eur J Pharmacol, 1988, 150(1-2), 9-14. 2. Jalonen J, et al. Anesthesiology, 1997, 86(2), 331-345. 3. Zhu Y X, Zhou J H, Li G W, et al. Dexmedetomidine protects liver cell line L-02 from oxygen-glucose deprivation-induced injury by down-regulation of microRNA-711[J]. European review for medical and pharmacological sciences. 2018 Oct;22(19):6507-6516.

TargetMolCitations

1. Zhu Y X, Zhou J H, Li G W, et al. Dexmedetomidine protects liver cell line L-02 from oxygen-glucose deprivation-induced injury by down-regulation of microRNA-711. European Review for Medical and Pharmacological Sciences. 2018 Oct;22(19):6507-6516 2. Hou Z, Yang F, Chen K, et al.hUC-MSC-EV-miR-24 enhances the protective effect of dexmedetomidine preconditioning against myocardial ischemia–reperfusion injury through the KEAP1/Nrf2/HO-1 signaling.Drug Delivery and Translational Research.2023: 1-15. 3. Zhang Q, Huang Y, Gong C, et al.Dexmedetomidine attenuates inflammation and organ injury partially by upregulating Nur77 in sepsis.Immunity, Inflammation and Disease.2023, 11(6): e883. 4. Ren W, Chen J, Wang W, et al.Sympathetic nerve-enteroendocrine L cell communication modulates GLP-1 release, brain glucose utilization, and cognitive function.Neuron.2024

Related compound libraries

This product is contained In the following compound libraries:
Anti-Neurodegenerative Disease Compound Library Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library Anti-Cancer Approved Drug Library Anti-Cancer Active Compound Library Endocrinology-Hormone Compound Library Human Metabolite Library Coagulation and Anticoagulation Compound Library NO PAINS Compound Library Clinical Compound Library

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Keywords

Dexmedetomidine 113775-47-6 GPCR/G Protein Neuroscience Adrenergic Receptor analgesia Inhibitor (S)-Medetomidine adrenoceptor inhibit (+)-Medetomidine Beta Receptor sedation anxiolysis inhibitor

 

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