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Dexmedetomidine

Catalog No. T2524 CAS 113775-47-6

Dexmedetomidine is a Central alpha-2 Adrenergic Agonist. The mechanism of action of dexmedetomidine is as an Adrenergic alpha2-Agonist. The physiologic effect of dexmedetomidine is by means of General Anesthesia.

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Dexmedetomidine, CAS 113775-47-6

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Purity: 98%

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Storage & Solubility Information

Description	Dexmedetomidine is a Central alpha-2 Adrenergic Agonist. The mechanism of action of dexmedetomidine is as an Adrenergic alpha2-Agonist. The physiologic effect of dexmedetomidine is by means of General Anesthesia.
Targets&IC50	α2 receptor:1.08 nM(Ki )
In vitro	Dexmedetomidine has a relatively high ratio of α2/α1-activity (1620:1 as compared with 220:1 for clonidine) and, therefore, is considered a full agonist of the α2 receptor. This may result in more potent effects of sedation without unwanted cardiovascular effects from α1 receptor activation. The 2-h half-life of dexmedetomidine is nearly 4-fold shorter than that of clonidine, which increases the likelihood that a continuous infusion of dexmedetomidine might be useful for sedation. Dexmedetomidine also has minimum alveolar anesthetic concentration (MAC)-sparing properties, but its use as an anesthetic adjuvant has been complicated by persistent hypotension that has mandated IV fluid administration and vasopressor administration. In addition, its use in large doses is complicated by hypertension from α2 receptor-mediated vascular constriction.

Molecular Weight	200.285
Formula	C13H16N2
CAS No.	113775-47-6

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 40 mg/mL (199.72 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Virtanen R, et al. Eur J Pharmacol, 1988, 150(1-2), 9-14. 2. Jalonen J, et al. Anesthesiology, 1997, 86(2), 331-345. 3. Zhu Y X, Zhou J H, Li G W, et al. Dexmedetomidine protects liver cell line L-02 from oxygen-glucose deprivation-induced injury by down-regulation of microRNA-711[J]. European review for medical and pharmacological sciences. 2018 Oct;22(19):6507-6516.

Citations

1. Zhu Y X, Zhou J H, Li G W, et al. Dexmedetomidine protects liver cell line L-02 from oxygen-glucose deprivation-induced injury by down-regulation of microRNA-711. European Review for Medical and Pharmacological Sciences. 2018 Oct;22(19):6507-6516

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Preclinical Compound Library GPCR Compound Library Anti-Cardiovascular Disease Compound Library Coagulation and Anticoagulation Compound Library Neurotransmitter Receptor Compound Library Endocrinology-Hormone Compound Library Anti-Alzheimer's Disease Compound Library Drug Repurposing Compound Library Anti-Cancer Approved Drug Library

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Keywords

Dexmedetomidine 113775-47-6 G蛋白偶联受体神经科学 Adrenergic Receptor analgesia Inhibitor (S)-Medetomidine adrenoceptor inhibit (+)-Medetomidine Beta Receptor sedation anxiolysis inhibitor

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