store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DSM265 (PfSPZ) is a dihydroorotic acid dehydrogenase inhibitor with antimalarial activity (IC50: 8.9 nM).DSM265 inhibits the growth of Pf3D7 parasites and can be used for the treatment and prophylaxis of malaria infections.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 30.00 | |
2 mg | In stock | $ 40.00 | |
5 mg | In stock | $ 64.00 | |
10 mg | In stock | $ 89.00 | |
25 mg | In stock | $ 144.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 68.00 |
Description | DSM265 (PfSPZ) is a dihydroorotic acid dehydrogenase inhibitor with antimalarial activity (IC50: 8.9 nM).DSM265 inhibits the growth of Pf3D7 parasites and can be used for the treatment and prophylaxis of malaria infections. |
Targets&IC50 | PfDHODH:8.9 nM, P. falciparum (3D7 parasites):4.3 nM (EC50) |
In vivo | In NOD-scid IL-2Rγnull (NSG) mice (23-36 g), DSM265 (0.5 - 75 mg/kg; oral administration; twice daily; for 4 days) exhibited potent antimalarial activity[2]. |
Synonyms | PfSPZ |
Molecular Weight | 415.33 |
Formula | C14H12F7N5S |
CAS No. | 1282041-94-4 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: < 0.1 mg/mL (insoluble.)
Ethanol: 5 mg/mL (12.04 mM), Sonication is recommended.
DMSO: 30 mg/mL (72.23 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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DSM265 1282041-94-4 Metabolism Microbiology/Virology Dehydrogenase Parasite PfSPZ DSM-265 DSM 265 inhibitor inhibit