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Cyclopenthiazide

Catalog No. T21469 CAS 742-20-1

Synonyms: Cyclomethiazide, Su-8341, SU 8341

Cyclopenthiazide (Cyclomethiazide) is a thiazide diuretic used to treat hypertension and heart failure. It decreases the excretion of calcium ions and uric acid and increases the excretion of sodium and potassium ions.

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Cyclopenthiazide, CAS 742-20-1

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Purity: 99.87%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Cyclopenthiazide (Cyclomethiazide) is a thiazide diuretic used to treat hypertension and heart failure. It decreases the excretion of calcium ions and uric acid and increases the excretion of sodium and potassium ions.
In vivo	Cyclopenthiazide 125 micrograms, a dose lower than is currently marketed, produced a similar hypotensive response to 500 micrograms of the drug without upsetting the biochemical profile[3].

Synonyms	Cyclomethiazide, Su-8341, SU 8341
Molecular Weight	379.88
Formula	C13H18ClN3O4S2
CAS No.	742-20-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: Soluble

H2O: Insoluble

References and Literature

1. Krum H, Jackson B, Conway EL, Howes LG, Johnston CI, Louis WJ. Steady-state pharmacokinetics and pharmacodynamics of cilazapril in the presence and absence of cyclopenthiazide. J Cardiovasc Pharmacol. 1992 Sep;20(3):451-7. PubMed PMID: 1279292. 2. Passmore AP, Whitehead EM, Crawford V, McVeigh GE, Johnston GD. The antihypertensive and metabolic effects of low and conventional dose cyclopenthiazide in type II diabetics with hypertension. Q J Med. 1991 Nov;81(295):919-28. PubMed PMID: 1808632. 3. Mcveigh G E , Galloway D B , Johnston D . The case for low dose diuretics in hypertension: Comparison of low and conventional doses of cyclopenthiazide[J]. BMJ Clinical Research, 1988, 297(6641):95-98. 4. Allman S, Norris RJ. An open, parallel group study comparing a frusemide/amiloride diuretic and a diuretic containing cyclopenthiazide with sustained release potassium in the treatment of congestive cardiac failure--a multicentre general practice study. J Int Med Res. 1990;18 Suppl 2:17B-23B. PubMed PMID: 2193840.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Bioactive Compound Library Anti-Hypertension Compound Library Anti-Cardiovascular Disease Compound Library Approved Drug Library FDA-Approved & Pharmacopeia Drug Library ReFRAME Related Library Human Metabolite Library NO PAINS Compound Library Bioactive Compounds Library Max

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Cyclopenthiazide 742-20-1 Others polycyclic aromatic hydrocarbons benzothiadiazine diuretic Cyclomethiazide Su-8341 sodium chloride inhibit SU 8341 Inhibitor SU-8341 SU8341 diuretic water inhibitor

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