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Corrector C4

Catalog No. T31014 CAS 421580-53-2

Synonyms: Corr 4a, Corrector C-4, Corr4a, Corrector C 4, Corr-4a

Corrector C4, a corrector commonly used to study cystic fibrosis mutants, works by alleviating the interaction between CFTR transmembrane domain mutants and protein homeostasis.

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Corrector C4, CAS 421580-53-2

Pack Size	Availability	Price/USD
1 mg	In stock	$ 195.00
5 mg	In stock	$ 483.00
10 mg	In stock	$ 692.00
25 mg	In stock	$ 1,080.00
50 mg	In stock	$ 1,490.00
100 mg	In stock	$ 1,970.00
500 mg	In stock	$ 3,930.00

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Purity: 98.64%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Corrector C4, a corrector commonly used to study cystic fibrosis mutants, works by alleviating the interaction between CFTR transmembrane domain mutants and protein homeostasis.

Synonyms	Corr 4a, Corrector C-4, Corr4a, Corrector C 4, Corr-4a
Molecular Weight	456.97
Formula	C21H17ClN4O2S2
CAS No.	421580-53-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/mL (131.3 mM)

References and Literature

1. Laselva O,et al. Correctors of the Major Cystic Fibrosis Mutant Interact through Membrane-Spanning Domains. Mol Pharmacol. 2018 Jun;93(6):612-618. 2. van der Woerd WL, et al. Rescue of defective ATP8B1 trafficking by CFTR correctors as a therapeutic strategy for familial intrahepatic cholestasis. J Hepatol. 2016 Jun;64(6):1339-47. 3. Bali V, et al. A synonymous codon change alters the drug sensitivity of ΔF508 cystic fibrosis transmembrane conductance regulator. FASEB J. 2016 Jan;30(1):201-13. 4. Dekkers JF,et al. Optimal correction of distinct CFTR folding mutants in rectal cystic fibrosis organoids. Eur Respir J. 2016 Aug;48(2):451-8.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Corrector C4 421580-53-2 Others Corr 4a Corrector C-4 Corr4a Corrector C 4 Corr-4a inhibitor inhibit

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