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Corin

Name: Corin
Brand: TargetMol
SKU: T10864
Price: 179 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T10864Cas No. 1808113-09-8

Corin is an irreversible inhibitor of HDAC1(IC50 = 147 nM) and LSD1(Ki = 110 nM).

Corin

🥰Excellent

Purity: 99.6%

Catalog No. T10864Cas No. 1808113-09-8

Corin is an irreversible inhibitor of HDAC1(IC50 = 147 nM) and LSD1(Ki = 110 nM).

Pack Size	Price	Availability
1 mg	$179	In Stock
5 mg	$455	In Stock
10 mg	$672	In Stock
25 mg	$1,060	In Stock
50 mg	$1,430	In Stock
100 mg	$1,920	In Stock
1 mL x 10 mM (in DMSO)	$490	In Stock

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Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.6%

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COA HNMR LCMS LCMS

Product Introduction

Bioactivity

Description	Corin is an irreversible inhibitor of HDAC1(IC50 = 147 nM) and LSD1(Ki = 110 nM).
Targets&IC50	HDAC1:147 nM , LSD1:110 nM
In vitro	Corin induces cellular H3K9 acetylation(EC50 = 95 nM) and is non-toxic to primary human melanocytes[1].

Chemical Properties

Molecular Weight	428.53
Formula	C₂₆H₂₈N₄O₂
Cas No.	1808113-09-8
Smiles	N[C@@H]1C[C@H]1c1ccc(NC(=O)CCCc2ccc(cc2)C(=O)Nc2ccccc2N)cc1
Relative Density.	1.287 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: Insoluble

DMSO: 90.0 mg/mL (210.0 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3336 mL	11.6678 mL	23.3356 mL	116.6779 mL
5 mM	0.4667 mL	2.3336 mL	4.6671 mL	23.3356 mL
10 mM	0.2334 mL	1.1668 mL	2.3336 mL	11.6678 mL
20 mM	0.1167 mL	0.5834 mL	1.1668 mL	5.8339 mL
50 mM	0.0467 mL	0.2334 mL	0.4667 mL	2.3336 mL
100 mM	0.0233 mL	0.1167 mL	0.2334 mL	1.1668 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc