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Corin

Name: Corin
Brand: TargetMol
SKU: T10864
Price: 179 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T10864Cas No. 1808113-09-8

Corin is an irreversible inhibitor of HDAC1(IC50 = 147 nM) and LSD1(Ki = 110 nM).

Corin

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Purity: 99.6%

Catalog No. T10864Cas No. 1808113-09-8

Corin is an irreversible inhibitor of HDAC1(IC50 = 147 nM) and LSD1(Ki = 110 nM).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$179	In Stock	In Stock
5 mg	$455	In Stock	In Stock
10 mg	$672	In Stock	In Stock
25 mg	$1,060	In Stock	In Stock
50 mg	$1,430	-	In Stock
100 mg	$1,920	-	In Stock
1 mL x 10 mM (in DMSO)	$490	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.6%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Corin is an irreversible inhibitor of HDAC1(IC50 = 147 nM) and LSD1(Ki = 110 nM).
Targets&IC50	HDAC1:147 nM , LSD1:110 nM
In vitro	Corin induces cellular H3K9 acetylation(EC50 = 95 nM) and is non-toxic to primary human melanocytes[1].

Chemical Properties

Molecular Weight	428.53
Formula	C₂₆H₂₈N₄O₂
Cas No.	1808113-09-8
Smiles	N[C@@H]1C[C@H]1c1ccc(NC(=O)CCCc2ccc(cc2)C(=O)Nc2ccccc2N)cc1
Relative Density.	1.287 g/cm3 (Predicted)

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: Insoluble

DMSO: 150 mg/mL (350.03 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (7.7 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3336 mL	11.6678 mL	23.3356 mL	116.6779 mL
5 mM	0.4667 mL	2.3336 mL	4.6671 mL	23.3356 mL
10 mM	0.2334 mL	1.1668 mL	2.3336 mL	11.6678 mL
20 mM	0.1167 mL	0.5834 mL	1.1668 mL	5.8339 mL
50 mM	0.0467 mL	0.2334 mL	0.4667 mL	2.3336 mL
100 mM	0.0233 mL	0.1167 mL	0.2334 mL	1.1668 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc