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Calcium dobesilate

Catalog No. T5939 CAS 20123-80-2

Calcium dobesilate(CaD) has angioprotective properties and protects endothelial cells partly by ameliorating HG induced inflammation.

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Calcium dobesilate, CAS 20123-80-2

Pack Size	Availability	Price/USD	Quantity
500 mg	In stock	$ 41.00
1 mL * 10 mM (in DMSO)	In stock	$ 45.00

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Purity: 98%

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Description	Calcium dobesilate(CaD) has angioprotective properties and protects endothelial cells partly by ameliorating HG induced inflammation.
In vitro	CaD inhibited abnormal cell proliferation. high glucose (HG) treatment also significantly enhanced HVUEC migration compared to the control treatment. In contrast, CaD treatment partially inhibited HUVEC migration compared to HG exposure. HG?treated HUVECs exhibited increased FITC?BSA permeability compared to control cells cultured in medium alone; however, CaD application prevented the HG?induced increase in FITC?BSA permeability and suppressed HG?induced overexpression of endothelial markers (VEGF, VEGFR?2, endocan) and inflammation markers (ICAM?1, MCP?1, PTX3) in HUVECs. CaD has angioprotective properties and protects endothelial cells partly by ameliorating HG?induced inflammation[1].
Cell Research	HUVECs were seeded in 96-well culture plates (1×10^4 cells/well). Following 24 h, the control or experimental medium was added. At 12, 24, 48 and 72 h, 10 μl CCK-8 reagent was added to each well for 1 h. Absorbance values were recorded at a wavelength of 450 nm using a microplate reader[1].

Molecular Weight	229.2
Formula	C6H5O5SCa0.5
CAS No.	20123-80-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 150 mg/mL (358.50 mM)

References and Literature

1. Zhou Y, Yuan J, Qi C et al.Calcium dobesilate may alleviate diabetes‑induced endothelial dysfunction and inflammation.Mol Med Rep[J]. 2017 Dec;16(6):8635-8642. 2. Professor Hervé Allain, Ramelet A A , Polard E , et al. Safety of Calcium Dobesilate in Chronic Venous Disease, Diabetic Retinopathy and Haemorrhoids[J]. Drug Safety, 2004, 27(9):649-660.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Anti-Cancer Approved Drug Library Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Anti-Cancer Compound Library Apoptosis Compound Library Drug-Fragment Library Orally Active Compound Library Anti-Diabetic Compound Library Approved Drug Library

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Calcium dobesilate 20123-80-2 Apoptosis Others inhibit Inhibitor inhibitor

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