Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CGP 78608 hydrochloride is a specific antagonist at the glycine binding site of the NMDA receptor (IC50 = 6 nM). CGP 78608 hydrochloride exhibits anticonvulsant activity. CGP 78608 hydrochloride potentiates GluN1/GluN3A-mediated glycine currents (estimated EC50 = 26.3 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 87.00 | |
5 mg | In stock | $ 197.00 | |
10 mg | In stock | $ 243.00 | |
25 mg | In stock | $ 535.00 | |
50 mg | In stock | $ 773.00 | |
100 mg | In stock | $ 1,080.00 |
Description | CGP 78608 hydrochloride is a specific antagonist at the glycine binding site of the NMDA receptor (IC50 = 6 nM). CGP 78608 hydrochloride exhibits anticonvulsant activity. CGP 78608 hydrochloride potentiates GluN1/GluN3A-mediated glycine currents (estimated EC50 = 26.3 nM). |
Targets&IC50 | NMDAR:6 nM |
In vitro | CGP 78608 hydrochloride reduces ammonia-dependent cGMP synthesis and relieves ammonia neurotoxicity[2]. CGP-78608 hydrochloride reduces glycine sensitivity of GluN1 and GluN3A receptors[3]. |
In vivo | CGP-78608 (i.p.) exhibits anticonvulsant effects in the electroshock-induced convulsions assay in mice[1]. |
Synonyms | PAMQX |
Molecular Weight | 414.58 |
Formula | C11H14BrClN3O5P |
CAS No. | 1135278-54-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 37.4 mg/mL (90.0 mM)
You can also refer to dose conversion for different animals. More
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CGP 78608 hydrochloride 1135278-54-4 Membrane transporter/Ion channel Neuroscience NMDAR iGluR CGP78608 Hydrochloride CGP 78608 Hydrochloride PAMQX CGP-78608 Hydrochloride inhibitor inhibit