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CGP 20712 A

Catalog No. T10778 CAS 105737-62-0

Synonyms: CGP 20712 mesylate

CGP 20712 A (CGP 20712 mesylate) is a highly selective antagonist of β1-adrenoceptor (IC50: 0.7 nM). It shows ~10,000-fold selectivity over β2-adrenoceptors.

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CGP 20712 A, CAS 105737-62-0

Pack Size	Availability	Price/USD
1 mg	In stock	$ 148.00
5 mg	In stock	$ 372.00
10 mg	In stock	$ 548.00
25 mg	In stock	$ 869.00
50 mg	In stock	$ 1,170.00
100 mg	In stock	$ 1,570.00

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Purity: 99.37%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	CGP 20712 A (CGP 20712 mesylate) is a highly selective antagonist of β1-adrenoceptor (IC50: 0.7 nM). It shows ~10,000-fold selectivity over β2-adrenoceptors.
Targets&IC50	β1-adrenoceptor:0.7 nM
In vitro	In myocytes, the activation of adenylate cyclase causes by β2-adrenoceptors is not detected in the presence of 10 nM, 100 nM, or 1000 nM CGP 20712 A [2].
In vivo	In 8-day-old rats, pretreatment with 5 mg/kg CGP 20712 A does not change the plasma ACTH response to insulin injection [3].

Synonyms	CGP 20712 mesylate
Molecular Weight	590.57
Formula	C24H29F3N4O8S
CAS No.	105737-62-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (169.33 mM), Sonication is recommended.

References and Literature

1. Dooley DJ, et al. CGP 20712 A: a useful tool for quantitating beta 1- and beta 2-adrenoceptors. Eur J Pharmacol. 1986 Oct 14;130(1-2):137-9. 2. Kitagawa Y, et al. Determination of beta-adrenoceptor subtype on rat isolated ventricular myocytes by use of highly selective beta-antagonists. Br J Pharmacol. 1995 Sep;116(1):1635-43. 3. Grino M, et al. Ontogeny of insulin-induced hypoglycemia stimulation of adrenocorticotropin secretion in the rat: role of catecholamines. Endocrinology. 1992 Dec;131(6):2763-8.

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Keywords

CGP 20712 A 105737-62-0 GPCR/G Protein Neuroscience Adrenergic Receptor CGP 20712 Mesylate CGP20712 Mesylate CGP-20712 Mesylate CGP 20712 mesylate inhibitor inhibit

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