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CCG-257081

Name: CCG-257081
Brand: TargetMol
SKU: T30778
Price: 129 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T30778Cas No. 1922098-90-5

Alias MRTF/SRF-IN-1, CCG257081, CCG 257081

CCG-257081 (MRTF/SRF-IN-1) is an inhibitor of cardiac myosin-related transcription factor and serum response factor (MRTF/SRF) that acts by inhibiting the Rho/MRTF/SRF pathway.CCG-257081 has shown efficacy in preventing bleomycin-induced fibrosis in several mouse models. CCG-257081 can be used in cancer prevention and fibrosis research.

CCG-257081

🥰Excellent

Purity: 99.87%

Catalog No. T30778Alias MRTF/SRF-IN-1, CCG257081, CCG 257081Cas No. 1922098-90-5

Pack Size	Price	Availability
1 mg	$129	In Stock
5 mg	$313	In Stock
10 mg	$466	In Stock
25 mg	$766	In Stock
50 mg	$1,070	In Stock
100 mg	$1,450	In Stock
500 mg	$2,880	In Stock

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Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.87%

Resource Download

COA FNMR HNMR LCMS

Product Introduction

Bioactivity

Description	CCG-257081 (MRTF/SRF-IN-1) is an inhibitor of cardiac myosin-related transcription factor and serum response factor (MRTF/SRF) that acts by inhibiting the Rho/MRTF/SRF pathway.CCG-257081 has shown efficacy in preventing bleomycin-induced fibrosis in several mouse models. CCG-257081 can be used in cancer prevention and fibrosis research.
Synonyms	MRTF/SRF-IN-1, CCG257081, CCG 257081

Chemical Properties

Molecular Weight	473.87
Formula	C₂₄H₁₉ClF₃N₃O₂
Cas No.	1922098-90-5
Smiles	C(=O)(C=1C=C(C=C(F)C1)C=2C=CN=CC2)N3CC(C(NC4=CC=C(Cl)C=C4)=O)CC(F)(F)C3
Relative Density.	1.42 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (105.51 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (10.55 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1103 mL	10.5514 mL	21.1028 mL	105.5142 mL
5 mM	0.4221 mL	2.1103 mL	4.2206 mL	21.1028 mL
10 mM	0.2110 mL	1.0551 mL	2.1103 mL	10.5514 mL
20 mM	0.1055 mL	0.5276 mL	1.0551 mL	5.2757 mL
50 mM	0.0422 mL	0.2110 mL	0.4221 mL	2.1103 mL
100 mM	0.0211 mL	0.1055 mL	0.2110 mL	1.0551 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc