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Brassinin

Catalog No. T4373 CAS 105748-59-2

Synonyms: BSN

Brassinin (BSN) (BSN) is a phytoalexin isolated from B. campestris that exhibits anticancer, chemopreventative, antiproliferative, and antifungal activities.

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Brassinin, CAS 105748-59-2

Pack Size	Availability	Price/USD
1 mg	In stock	$ 37.00
2 mg	In stock	$ 50.00
5 mg	In stock	$ 70.00
10 mg	In stock	$ 130.00
25 mg	In stock	$ 250.00
50 mg	In stock	$ 440.00
100 mg	In stock	$ 648.00
1 mL * 10 mM (in DMSO)	In stock	$ 110.00

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Purity: 98.25%

Biological Description

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Description	Brassinin (BSN) (BSN) is a phytoalexin isolated from B. campestris that exhibits anticancer, chemopreventative, antiproliferative, and antifungal activities.
In vitro	In lung cancer cells, brassinin inhibits constitutive and IL-6-inducible STAT3 signaling through modulation of PIAS-3 and SOCS-3.It appears that brassinin induces apoptosis in PC-3 prostate cancer cells via the suppression of PI3K/Akt/mTOR/S6K1 signaling.
In vivo	Brassinin attenuates tumor growth in a xenograft lung cancer mouse model through modulation of E3 SUMO-protein ligase 3 (PIAS-3) and suppressor of cytokine signaling-3 (SOCS-3).
Source	Natural Products > Brassicaceae > Brassica

Synonyms	BSN
Molecular Weight	236.36
Formula	C11H12N2S2
CAS No.	105748-59-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (232.71 mM)

References and Literature

1. Kim SM,etal.Brassinin induces apoptosis in PC-3 human prostate cancer cells through the suppression of PI3K/Akt/mTOR/S6K1 signaling cascades.Phytother Res. 2014 Mar;28(3):423-31. 2. Pedras MS,etal.Phytoalexins from the crucifer rutabaga: structures, syntheses, biosyntheses, and antifungal activity.J Org Chem. 2004 Jun 25;69(13):4471-6. 3. Lee JH,et al.Brassinin inhibits STAT3 signaling pathway through modulation of PIAS-3 and SOCS-3 expression and sensitizes human lung cancer xenograft in nude mice to paclitaxel.Oncotarget. 2015 Mar 20;6(8):6386-405.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Anti-Tumor Natural Product Library Natural Product Library for HTS Anti-Fungal Compound Library RO5 Drug-like Natural Product Library Natural Product Library Anti-infective Natural Product Library Bioactive Compounds Library Max Human Metabolite Library Selected Plant-Sourced Compound Library

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Keywords

Brassinin 105748-59-2 Microbiology/Virology Antifungal BSN Brassinine inhibit Inhibitor inhibitor

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