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Betaine chloride

Catalog No. T0019 CAS 590-46-5

Synonyms: Betaine hydrochloride

Betaine hydrochloride is an acidic form of betaine, a vitamin-like substance observed in grains and other foods; gains the amplification of <a href="/target/DNA" style="display: inline; color: #c13a36">DNA</a> by decreasing the formation of secondary structure in GC-rich regions.

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Betaine chloride, CAS 590-46-5

Pack Size	Availability	Price/USD	Quantity
50 mg	In stock	$ 50.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Betaine hydrochloride is an acidic form of betaine, a vitamin-like substance observed in grains and other foods; gains the amplification of DNA by decreasing the formation of secondary structure in GC-rich regions.

In vitro

It is found that proliferation of HeLa cells is inhibited significantly upon exposure to increasing Betaine hydrochloride levels with the MTT test (p<0.05). The percentage of S phase cells in the low dose groups (<5 mg/mL) are distinctly higher than in high dose groups while the rates of Sub-G1 phase are the opposite (p<0.05). A high concentration of Betaine hydrochloride (>5.0 mg/mL) significantly promotes the apoptosis of HeLa cells (p<0.01). SOD activities of the low dose groups are slightly higher than the control group (p<0.05), and there are obvious synchronicity and correlation among the expression of promoting apoptosis genes Bax, P53, Caspase 3 and apoptosis suppression gene Bcl-2. In response to an apoptosis-inducing stimulus, p53 and cyclin D1 can be activated with blockage of the cell cycle at G1/S or S/G2 checkpoints.

Synonyms	Betaine hydrochloride
Molecular Weight	153.61
Formula	C5H12ClNO2
CAS No.	590-46-5

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

H2O: 43 mg/mL (279.93 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Lee I. Biochem Biophys Res Commun. 2015 Jan 9;456(2):621-5.

Related compound libraries

This product is contained In the following compound libraries：

Selected Plant-Sourced Compound Library Bioactive Compound Library Natural Product Library Traditional Chinese Medicine Monomer Library Chinese Pharmacopoeia Natural Product Library FDA-Approved & Pharmacopeia Drug Library Ion Channel Inhibitor Library Bioactive Compounds Library Max NO PAINS Compound Library Drug-Fragment Library

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Keywords

Betaine chloride 590-46-5 Membrane transporter/Ion channel Metabolism Others Chloride channel Endogenous Metabolite Inhibitor Betaine inhibit Betaine hydrochloride inhibitor

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