Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Betaine hydrochloride is an acidic form of betaine, a vitamin-like substance observed in grains and other foods; gains the amplification of <a href="/target/DNA" style="display: inline; color: #c13a36">DNA</a> by decreasing the formation of secondary structure in GC-rich regions.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
50 mg | In stock | $ 50.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 50.00 |
Description | Betaine hydrochloride is an acidic form of betaine, a vitamin-like substance observed in grains and other foods; gains the amplification of DNA by decreasing the formation of secondary structure in GC-rich regions. |
In vitro | It is found that proliferation of HeLa cells is inhibited significantly upon exposure to increasing Betaine hydrochloride levels with the MTT test (p<0.05). The percentage of S phase cells in the low dose groups (<5 mg/mL) are distinctly higher than in high dose groups while the rates of Sub-G1 phase are the opposite (p<0.05). A high concentration of Betaine hydrochloride (>5.0 mg/mL) significantly promotes the apoptosis of HeLa cells (p<0.01). SOD activities of the low dose groups are slightly higher than the control group (p<0.05), and there are obvious synchronicity and correlation among the expression of promoting apoptosis genes Bax, P53, Caspase 3 and apoptosis suppression gene Bcl-2. In response to an apoptosis-inducing stimulus, p53 and cyclin D1 can be activated with blockage of the cell cycle at G1/S or S/G2 checkpoints. |
Synonyms | Betaine hydrochloride |
Molecular Weight | 153.61 |
Formula | C5H12ClNO2 |
CAS No. | 590-46-5 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
H2O: 43 mg/mL (279.93 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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Betaine chloride 590-46-5 Membrane transporter/Ion channel Metabolism Others Chloride channel Endogenous Metabolite Inhibitor Betaine inhibit Betaine hydrochloride inhibitor