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Benoxaprofen

Name: Benoxaprofen
Brand: TargetMol
SKU: T19679
Price: 213 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T19679Cas No. 51234-28-7

Alias NSC 299582, LY-90459, Benoxaphen. Compound 90459

Benoxaprofen (NSC-299582) is a non-steroidal anti-inflammatory drug.

Benoxaprofen

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Purity: 98.87%

Catalog No. T19679Alias NSC 299582, LY-90459, Benoxaphen. Compound 90459Cas No. 51234-28-7

Benoxaprofen (NSC-299582) is a non-steroidal anti-inflammatory drug.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$213	In Stock	In Stock
5 mg	$496	In Stock	In Stock
10 mg	$745	In Stock	In Stock
25 mg	$1,090	In Stock	In Stock
50 mg	$1,380	In Stock	In Stock
100 mg	$1,750	-	In Stock
1 mL x 10 mM (in DMSO)	$493	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:98.87%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Benoxaprofen AI Summary

Benoxaprofen demonstrates significant anti-inflammatory activity in both acute and subchronic inflammation models, with an ED50 of 15.0 mg/kg and an ED40 of 10.0 mg/kg, respectively. It shows good gastrointestinal tolerability in acute conditions with an ulcerogenic dose (UD) of over 200.0 mg/kg but has a much lower UD in chronic conditions, under 30.0 mg/kg. Safety assessments reveal minimal blood loss at doses less than 50.0 mg/kg and low lethality in rats at doses below 50.0 mg/kg. The compound has a pKa value of 6.9, suggesting varying levels of ionization at different pH conditions, and a high plasma protein binding activity of 99.76% with a LogD7.4 value of 1.3. It also exhibits specific activity in the UGT2B7 enzyme and shows inhibition of rat Bsep and human BSEP with IC50 values of 99100.0 nM and 175000.0 nM, respectively. Benoxaprofen also affects liver and kidney function, changing various biochemical parameters such as ALT, AST, ALP, BILI, BUN, CREAT, RBC, WBC, PLAT, CHLORIDE, SODIUM, POTASSIUM, ALB, and PROT. The compound has been evaluated in DILIps datasets, showing a DILI score of 1.0, suggesting potential drug-induced liver injury. It has an LD50 of 800.0 mg/kg when administered orally and a terminal half-life of 19.0 hours in humans. Additionally, it demonstrates antiviral activity against SARS-CoV-2 with an IC50 greater than 20000.0 nM and inhibits human BSEP with an IC50 of 103700.0 nM. Benoxaprofen affects drug metabolism in human Hep3B cells, impacting CYP3A4, CYP2D6, and CYP2C9 activities, and shows binding affinities towards various receptors and transporters, including human MAOA and CCKBR..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Benoxaprofen (NSC-299582) is a non-steroidal anti-inflammatory drug.
Synonyms	NSC 299582, LY-90459, Benoxaphen. Compound 90459

Chemical Properties

Molecular Weight	301.72
Formula	C₁₆H₁₂ClNO₃
Cas No.	51234-28-7
Smiles	C(C(O)=O)(C)C=1C=C2C(OC(=N2)C3=CC=C(Cl)C=C3)=CC1
Relative Density.	1.2411 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (198.86 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3143 mL	16.5717 mL	33.1433 mL	165.7166 mL
5 mM	0.6629 mL	3.3143 mL	6.6287 mL	33.1433 mL
10 mM	0.3314 mL	1.6572 mL	3.3143 mL	16.5717 mL
20 mM	0.1657 mL	0.8286 mL	1.6572 mL	8.2858 mL
50 mM	0.0663 mL	0.3314 mL	0.6629 mL	3.3143 mL
100 mM	0.0331 mL	0.1657 mL	0.3314 mL	1.6572 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc