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Bederocin

Catalog No. T30311 CAS 757942-43-1

Synonyms: REP 8839, REP-8839, REP8839

Bederocin (REP8839)is a novel inhibitor of methionyl tRNA synthase (METS) with potent antibacterial activity against clinical isolates of Staphylococcus aureus, Streptococcus pyogenes, and other clinically important Gram-positive bacteria.

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Bederocin, CAS 757942-43-1

Pack Size	Availability	Price/USD	Quantity
5 mg	6-8 weeks	$ 138.00
10 mg	6-8 weeks	$ 225.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Bederocin (REP8839)is a novel inhibitor of methionyl tRNA synthase (METS) with potent antibacterial activity against clinical isolates of Staphylococcus aureus, Streptococcus pyogenes, and other clinically important Gram-positive bacteria.
Targets&IC50	MetRS:0.01 µM(Ki)

Synonyms	REP 8839, REP-8839, REP8839
Molecular Weight	450.37
Formula	C20H21BrFN3OS
CAS No.	757942-43-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Hussain T, et al. Inhibition of protein synthesis and malaria parasite development by drug targeting of methionyl-tRNA synthetases. Antimicrob Agents Chemother. 2015 ; 59(4):1856-1867. 2. Faqi AS, et al. An intranasal irritation assessment of antibacterial ointment alone or in combination with mupirocin versus Bactroban Nasal in rabbits. Regul Toxicol Pharmacol. 2009 ; 55(1):28-32. 3. Green LS, et al. Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity. Antimicrob Agents Chemother. 2009 ; 53(1):86-94. 4. Critchley IA, et al. Recent advances in the preclinical evaluation of the topical antibacterial agent REP8839. Curr Opin Chem Biol. 2008 ; 12(4):409-417.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Bederocin 757942-43-1 Microbiology/Virology Antibacterial REP 8839 REP-8839 REP8839 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.