store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BW 245C is a selective prostaglandin-like DP receptor (DP1) agonist, a prostaglandin analogue with inhibitory effects on the aggregation response of collagen, which can be used to study diseases such as stroke.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 199.00 |
Description | BW 245C is a selective prostaglandin-like DP receptor (DP1) agonist, a prostaglandin analogue with inhibitory effects on the aggregation response of collagen, which can be used to study diseases such as stroke. |
In vitro | The prostaglandin DP receptor agonist BW 245C (0.01-1μM) inhibited TGF-β-induced collagen secretion and increased intracellular cAMP in lung fibroblasts [3]. The use of the DP receptor agonist BW 245C (0.1-3μmol/L) dose-dependently increased the transendothelial resistance of human umbilical vein endothelial cells and decreased FITC-dextran permeability. Moreover, it elevated intracellular cAMP levels and subsequent protein kinase A (PKA) activity [4]. |
In vivo | Injection of the DP1 agonist BW 245C (100 nM, 20 uL) did not significantly increase MBP-positive eosinophils in the esophageal epithelial cells of OVA-sensitized guinea pigs [2]. WT and DP1 (-/-) mice underwent middle cerebral artery occlusion, followed by a single intraperitoneal injection of vehicle or 0.02, 0.2, or 2.0 mg/kg BW 245C, and then immediate reperfusion. The results showed that BW 245C treatment significantly increased baseline CBF in WT mice but not in DP1 (-/-) mice [1]. |
Synonyms | BW245C |
Molecular Weight | 368.47 |
Formula | C19H32N2O5 |
CAS No. | 72814-32-5 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 30 mg/mL (81.42 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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BW 245C 72814-32-5 GPCR/G Protein Immunology/Inflammation Prostaglandin Receptor BW245C inhibitor inhibit