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BRD 4354

Catalog No. T10602L CAS 315698-07-8

BRD 4354 is an inhibitor of HDAC5 and HDAC9. For HDAC5 and HDAC9, the IC50s values are 0.85 and 1.88 μM, respectively.

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BRD 4354, CAS 315698-07-8

Pack Size	Availability	Price/USD
2 mg	In stock	$ 39.00
5 mg	In stock	$ 64.00
10 mg	In stock	$ 113.00
25 mg	In stock	$ 228.00
50 mg	In stock	$ 397.00
100 mg	In stock	$ 589.00
1 mL * 10 mM (in DMSO)	In stock	$ 70.00

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Purity: 99.08%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	BRD 4354 is an inhibitor of HDAC5 and HDAC9. For HDAC5 and HDAC9, the IC50s values are 0.85 and 1.88 μM, respectively.
Targets&IC50	HDAC5:0.85 μM, HDAC9:1.88 μM
In vitro	BRD 4354 also inhibits HDACs 4, 6, 7, and 8 at higher concentrations (3.88-13.8 μM) but demonstrates less of an inhibitory effect on other class I HDACs 1, 2, and 3 (IC50>40 μM) [1]. BRD 4354 is a moderately potent inhibitor of HDAC5 and HDAC9, with BRD4354 having half-maximum inhibitory concentrations (IC50) of 0.85 μM and 1.88 μM, respectively.

Molecular Weight	382.89
Formula	C21H23ClN4O
CAS No.	315698-07-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 10 mg/mL (23.01 mM), Sonification is recommended.

References and Literature

1. Boskovic ZV, ET AL. Inhibition of Zinc-Dependent Histone Deacetylases with a Chemically Triggered Electrophile. ACS Chem Biol. 2016 Jul 15;11(7):1844-51.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Bioactive Compounds Library Max NF-κB Signaling Compound Library Reprogramming Compound Library Anti-Breast Cancer Compound Library Anti-Cancer Compound Library DNA Damage & Repair Compound Library Anti-Pancreatic Cancer Compound Library Bioactive Compound Library Chromatin Modification Compound Library

Related Products

Related compounds with same targets

ACY-957 Phenylethyl isothiocyanate Tenovin-6 Hydrochloride HDAC6-IN-24 HDAC8-IN-1 HDAC6 degrader 9c HPOB HDAC6-IN-18

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

BRD 4354 315698-07-8 Chromatin/Epigenetic DNA Damage/DNA Repair HDAC Histone deacetylases inhibit Inhibitor BRD4354 BRD-4354 inhibitor

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