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BMS-707035

BMS-707035
BMS-707035 is a specific HIV-I integrase (IN) inhibitor with IC50 of 15 nM. Phase 2.
Catalog No. T6420Cas No. 729607-74-3
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Purity:99.78%
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BMS-707035

Catalog No. T6420Cas No. 729607-74-3
BMS-707035 is a specific HIV-I integrase (IN) inhibitor with IC50 of 15 nM. Phase 2.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
2 mg$34In Stock
5 mg$55In Stock
10 mg$98In Stock
25 mg$197In Stock
50 mg$360In Stock
100 mg$587In Stock
1 mL x 10 mM (in DMSO)$61In Stock
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Product Introduction

Bioactivity
Description
BMS-707035 is a specific HIV-I integrase (IN) inhibitor with IC50 of 15 nM. Phase 2.
Targets&IC50
HIV-I integrase:15 nM
In vitro
BMS-707035 is a pyrimidine carboxamide similar to Raltegravir, the first integrase inhibitor licensed for clinical use. BMS-707035 is a potent, specific, and reversible HIV-I integrase (IN) inhibitor that blocks HIV IN strand transfer activity with IC50 of 15 nM. [1] However, several IN mutations, including V75I, Q148R, V151I, and G163R are found to confer resistance to HIV IN inhibitors. The binding of BMS-707035 and target DNA to IN are mutually exclusive events, as revealed by the fact that the inhibition of strand transfer catalysis by BMS-707035 is overcome by increasing amount of target DNA. The binding affinity of BMS-707035 to IN is also affected by the four terminal bases at the 5' end of the pre-processed U5 long terminal repeat (LTR). Gln148 of IN is crucial for the binding of BMS-707035 to IN. [1] The 3' terminus of the viral LTR, on the other hand, retards the rate of BMS-707035 association with IN, by regulating the kinetics of binding and dissociation. [2]
Chemical Properties
Molecular Weight410.42
FormulaC17H19FN4O5S
Cas No.729607-74-3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
H2O: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 36 mg/mL (87.7 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.4365 mL12.1826 mL24.3653 mL121.8264 mL
5 mM0.4873 mL2.4365 mL4.8731 mL24.3653 mL
10 mM0.2437 mL1.2183 mL2.4365 mL12.1826 mL
20 mM0.1218 mL0.6091 mL1.2183 mL6.0913 mL
50 mM0.0487 mL0.2437 mL0.4873 mL2.4365 mL

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