store at low temperature,keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BI8626 is a ubiquitin ligase HUWE1 inhibitor with protective effects against spontaneous desiccation syndrome in NOD/ShiLtj mice.BI8626 inhibits intracellular cholesterol and decreases the expression of phosphorylated ZAP-70, CD25, and other activation markers, and inhibits the proliferation of CD4 T-cells.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 84.00 | |
5 mg | In stock | $ 198.00 | |
10 mg | In stock | $ 313.00 | |
25 mg | In stock | $ 528.00 | |
50 mg | In stock | $ 752.00 | |
100 mg | In stock | $ 987.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 226.00 |
Description | BI8626 is a ubiquitin ligase HUWE1 inhibitor with protective effects against spontaneous desiccation syndrome in NOD/ShiLtj mice.BI8626 inhibits intracellular cholesterol and decreases the expression of phosphorylated ZAP-70, CD25, and other activation markers, and inhibits the proliferation of CD4 T-cells. |
Targets&IC50 | HUWE1:0.9 μM |
In vitro | In LS174T cells, BI8626 (0μM, 5μM, 10μM, 15μM, 20μM; 0-4 days) delayed progression through all phases of the cell cycle, with the most pronounced effect on the G1 phase[1]. |
Molecular Weight | 440.54 |
Formula | C25H28N8 |
CAS No. | 1875036-75-1 |
store at low temperature,keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 60 mg/mL (136.20 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
BI8626 1875036-75-1 Ubiquitination E1/E2/E3 Enzyme BI-8626 BI 8626 inhibitor inhibit