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Artesunate

Catalog No. T0433 CAS 88495-63-0

Synonyms: WR-256283

Artesunate (WR-256283) is part of the artemisinin group of drugs that treat malaria. It is a semi-synthetic derivative of artemisinin that is water-soluble and may therefore be given by injection. It is on the World Health Organization's List of Essential Medicines.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Artesunate, CAS 88495-63-0

Pack Size	Availability	Price/USD
25 mg	In stock	$ 33.00
50 mg	In stock	$ 47.00
100 mg	In stock	$ 77.00
200 mg	In stock	$ 113.00
500 mg	In stock	$ 187.00
1 mL * 10 mM (in DMSO)	In stock	$ 52.00

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Purity: 99.91%

Purity: 99.9%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Artesunate (WR-256283) is part of the artemisinin group of drugs that treat malaria. It is a semi-synthetic derivative of artemisinin that is water-soluble and may therefore be given by injection. It is on the World Health Organization's List of Essential Medicines.
In vitro	ART could alter the biomechanical properties of the glioma cells to inhibit cell proliferation, migration and invasion [2]. The ART significantly suppresses the cell proliferation, induces the apoptosis and promoted cell cycle arrest at G0/G1 phase in SKM-1 cells. The mechanisms of ART anti-MDS is associated with the increase of intracellular calciumion concentration and ROS levels. In addition, the pro-apoptotic activity of ART may be involved in the regulation of BCL-2 /BAX ratio and the expressions of P-bad and survivin[3]. ART treatment demethylates CDH1, which, in turn recovers the E-cadherin activation in SKM-1 cells[1].
In vivo	Artesunate is a medication used to treat malaria. Artesunate can induce radiosensitivity of HeLa cells in vivo using Xenograft model of nude mice[5]. Artesunate had a relatively high immunosuppressive activity with low toxicity, and could inhibit T lymphocyte proliferation induced by mitogen and alloantigen[6].
Cell Research	Growth inhibition assay: The SKM-1 cells (1×105/mL) are firstly seeded in 96-well plates. Artesunate is diluted in 0.1% dimethyl sulfoxide (DMSO) producing 0, 12.5, 25, 50µg/mL concentrations and added to the SKM-1 cells with 100 µl per well. A negative control is treated with 0.1% DMSO. At 0, 24, 48, and 72 hours, same amount of MTT solution is added into each well and cultured for extra 4 hours. MTT treated cells are fixed with 150 µL DMSO for 30 min at room temperature and then determined with Evolution 201 and 220 UV-Vis spectrophotometer system at 540 nm. (Only for Reference)
Source	Natural Products > Asteraceae > Artemisia

Synonyms	WR-256283
Molecular Weight	384.42
Formula	C19H28O8
CAS No.	88495-63-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 9 mg/mL(23.4 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 71 mg/mL (184.7 mM)

References and Literature

1. Xu N, et al. Int J Med Sci. 2015, 12(6):524-529. 2. Lian S, et al. Oncol Rep. 2016, 36(2):984-1990. 3. Qiao SK, et al. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2016, 24(1):131-137. 4. Lisewski AM, et al. Cell. 2014, 158(4):916-928. 5. Luo J, et al.Radiat Oncol. 2014, 9:84. 6. Wang B, et al. Artesunate sensitizes ovarian cancer cells to cisplatin by downregulating RAD51. Cancer Biol Ther. 2015;16(10):1548-56. 7. Ilamathi M, et al. Artesunate as an Anti-Cancer Agent Targets Stat-3 and Favorably Suppresses Hepatocellular Carcinoma. Curr Top Med Chem. 2016;16(22):2453-63. 8. Bowden G D, Land K M, O'Connor R M, et al. High-throughput screen of drug repurposing library identifies inhibitors of Sarcocystis neurona growth[J]. International Journal for Parasitology: Drugs and Drug Resistance. 2018 Apr；8(1): 137-144.

Citations

1. Liu Y, Li H, Luo Z, et al. Artesunate, a new antimalarial clinical drug, exhibits potent anti‐AML activity by targeting the ROS/Bim and TFRC/Fe2+ pathways. British Journal of Pharmacology. 2022 2. Jin J, Guo D, Wang Y, et al. Artesunate Inhibits the Development of Esophageal Cancer by Targeting HK1 to Reduce Glycolysis Levels in Areas With Zinc Deficiency. Frontiers in Oncology. 2022: 1956 3. Bowden G D, Land K M, O'Connor R M, et al. High-throughput screen of drug repurposing library identifies inhibitors of Sarcocystis neurona growth. International Journal for Parasitology: Drugs and Drug Resistance. 2018 Apr；8(1): 137-144 4. Wang J, Zhang J, Guo Z, et al.Targeting HSP70 chaperones by rhein sensitizes liver cancer to artemisinin derivatives.Phytomedicine.2023: 155156. 5. Han X, Jiang S, Hu C, et al.Inhibition of Keloid Fibroblast Proliferation by Artesunate is Mediated by Targeting the IRE1α/XBP1 Signaling Pathway and Decreasing TGF-β1.Burns.2024

Related compound libraries

This product is contained In the following compound libraries：

Antiparasitic Natural Product Library Anti-Cancer Drug Library Anti-Cancer Approved Drug Library Anti-Parasitic Compound Library Traditional Chinese Medicine Monomer Library EMA Approved Drug Library Drug Repurposing Compound Library Anti-Cancer Clinical Compound Library Anti-Cancer Metabolism Compound Library Cell Cycle Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Artesunate 88495-63-0 Apoptosis JAK/STAT signaling Microbiology/Virology Stem Cells STAT Parasite Ferroptosis Virus Protease inhibit WR256283 WR 256283 WR-256283 Inhibitor inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.