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Almonertinib hydrochloride

Catalog No. T5675 CAS 2134096-03-8

Synonyms: HS-10296 hydrochloride

Almonertinib hydrochloride (HS-10296 hydrochloride) is a small molecule inhibitor of EGFR-activating mutations and T790M-resistant mutation with limited activity against wild-type EGFR.

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Almonertinib hydrochloride Chemical Structure

Almonertinib hydrochloride, CAS 2134096-03-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 93.00
5 mg	In stock	$ 195.00
10 mg	In stock	$ 328.00
25 mg	In stock	$ 565.00
50 mg	In stock	$ 793.00

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Purity: 98.01%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Almonertinib hydrochloride (HS-10296 hydrochloride) is a small molecule inhibitor of EGFR-activating mutations and T790M-resistant mutation with limited activity against wild-type EGFR.
Targets&IC50	EGFR (T790M):0.37 nM (IC50), EGFR (del19/T790M):0.214 nM (IC50), EGFR (L858R/T790M):0.29 mM (IC50)
In vitro	HS-10296 hydrochloride is an orally available inhibitor of the epidermal growth factor receptor (EGFR) mutant form T790M, with potential antineoplastic activity, which canbe used to treat NSCLC[1].

Synonyms	HS-10296 hydrochloride
Molecular Weight	562.1
Formula	C30H36ClN7O2
CAS No.	2134096-03-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 83.33 mg/mL (148.25 mM), Sonication is recommended.

References and Literature

1. Ivana S , David P . Next-Generation EGFR Tyrosine Kinase Inhibitors for Treating EGFR-Mutant Lung Cancer beyond First Line[J]. Frontiers in Medicine, 2017, 3. 2. Wu S G , Shih J Y . Management of acquired resistance to EGFR TKI–targeted therapy in advanced non-small cell lung cancer[J]. Molecular Cancer, 2018, 17(1):38.

Related compound libraries

This product is contained In the following compound libraries：

NO PAINS Compound Library Approved Drug Library Cytokine Inhibitor Library Reprogramming Compound Library Cysteine Covalent Library

Related Products

Related compounds with same targets

Mutated EGFR-IN-1 CGP52411 Icotinib Hydrochloride Epitinib succinate Multi-target kinase inhibitor 2 Osimertinib mesylate EGFR-IN-8 Neolinine

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Almonertinib hydrochloride 2134096-03-8 Angiogenesis JAK/STAT signaling Tyrosine Kinase/Adaptors EGFR HS10296 non-small inhibit oral cancer lung HS-10296 hydrochloride del19 antineoplastic HS-10296 mutations Epidermal growth factor receptor L861Q HS 10296 Hydrochloride G719X Inhibitor NSCLC HS-10296 Hydrochloride Almonertinib Hydrochloride ErbB-1 HS10296 Hydrochloride L858R cell Almonertinib HS 10296 HER1 inhibitor

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