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Abemaciclib methanesulfonate

Catalog No. T3111 CAS 1231930-82-7

Synonyms: abemaciclib mesylate, LY2835219, LY2835219 mesylate, LY2835219 (methanesulfonate)

Abemaciclib methanesulfonate (LY2835219) is a specific and effective inhibitor of CDK4(IC50=2 nM) and CDK6(IC50=10 nM).

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Abemaciclib methanesulfonate Chemical Structure

Abemaciclib methanesulfonate, CAS 1231930-82-7

Pack Size	Availability	Price/USD
2 mg	In stock	$ 30.00
5 mg	In stock	$ 50.00
10 mg	In stock	$ 72.00
25 mg	In stock	$ 86.00
50 mg	In stock	$ 98.00
100 mg	In stock	$ 126.00
200 mg	In stock	$ 157.00
1 mL * 10 mM (in DMSO)	In stock	$ 67.00

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Purity: 99.1%

Purity: 98%

Purity: 98.00%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Abemaciclib methanesulfonate (LY2835219) is a specific and effective inhibitor of CDK4(IC50=2 nM) and CDK6(IC50=10 nM).
Targets&IC50	CDK4:2 nM, CDK6:10 nM
In vitro	In subcutaneous and intracranial glioma models (U87 mg), MsOH treatment results in LY2835219 inhibiting tumor growth in a dose-dependent manner.
In vivo	In retinoblastoma, LY2835219 inhibits cancer cell growth by specifically targeting and inhibiting CDK4 and CDK6, leading to cell cycle arrest at the G1 phase and suppression of DNA synthesis.
Kinase Assay	Cells (5 × 103) are plated in 96 well plates. Cells are treated the next day for 24 to 48 hours and then assessed for caspase-3 activity by Caspase-Glo-3/7 Assay, as per manufacturer's instructions and a luminescence plate reader.
Cell Research	LY2835219 is dissolved in DMSO to a 10 mM concentration.? Cells are seeded in a 96-well plate, allowed to adhere overnight, and treated with DMSO control (0.1% v/v) or the indicated compounds for 72 h. Cell viability and proliferation are determined using a Cell Counting Kit according to the manufacturer's instructions. The interaction between LY2835219 and mTOR inhibitor is determined using CompuSyn. Combination index (CI) values of 1 indicates and additive drug interaction, whereas a CI of < 1 is synergistic and a CI of > 1 is antagonistic.

Synonyms	abemaciclib mesylate, LY2835219, LY2835219 mesylate, LY2835219 (methanesulfonate)
Molecular Weight	602.7
Formula	C27H32F2N8·CH4O3S
CAS No.	1231930-82-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 45mg/mL (74.7mM)

DMSO: 77 mg/mL (127.8 mM)

Ethanol: 23 mg/mL (38.2 mM)

References and Literature

1. Sanchez-Martinez et al. Mol Cancer Ther, 2011,10(11 Suppl), Abstract nr B234. 2. Ou J, Li H, Qiu P, et al. CDK9 modulates circadian clock by attenuating REV-ERBα activity[J]. Biochemical and biophysical research communications. 2019 Jun 11;513(4):967-973.

Citations

1. Li Q, Jiang B, Guo J, et al. INK4 tumor suppressor proteins mediate resistance to CDK4/6 kinase inhibitors. Cancer Discovery. 2022, 12(2): 356-371. 2. Ou J, Li H, Qiu P, et al. CDK9 modulates circadian clock by attenuating REV-ERBα activity. Biochemical and Biophysical Research Communications. 2019 Jun 11;513(4):967-973

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library EMA Approved Drug Library Anti-Cancer Approved Drug Library Kinase Inhibitor Library Inhibitor Library Drug Repurposing Compound Library FDA-Approved Kinase Inhibitor Library Anti-Cancer Active Compound Library NO PAINS Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Abemaciclib methanesulfonate 1231930-82-7 Cell Cycle/Checkpoint CDK inhibit Inhibitor abemaciclib mesylate LY2835219 Cyclin dependent kinase LY2835219 mesylate LY 2835219 Abemaciclib LY2835219 Mesylate LY-2835219 LY-2835219 Mesylate LY2835219 (methanesulfonate) methanesulfonate LY 2835219 Mesylate abemaciclib Mesylate inhibitor

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