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Metabolism Dehydrogenase ASLAN003

ASLAN003

Catalog No. T10384   CAS 1035688-66-4

ASLAN003 is an orally active and potent inhibitor of DHODH (Human Dihydroorotate Dehydrogenase) with antitumor activity. It has the potential to be a first-in-class candidate in AML.

ASLAN003, CAS 1035688-66-4
Pack Size Availability Price/USD Quantity
5 mg In stock 346.00
10 mg In stock 541.00
25 mg In stock 971.00
50 mg In stock 1616.00
100 mg In stock 2202.00
200 mg In stock inquiry
500 mg In stock inquiry
1 mL * 10 mM (in DMSO) In stock 272.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description ASLAN003 is an orally active and potent inhibitor of DHODH (Human Dihydroorotate Dehydrogenase) with antitumor activity. It has the potential to be a first-in-class candidate in AML.
Targets&IC50 DHODH,  
In vivo ASLAN003 substantially reduces leukemic burden and prolongs survival in acute myeloid leukemia xenograft mice and acute myeloid leukemia patient-derived xenograft models. Notably, the drug has no evident effect on normal hematopoietic cells and exhibits excellent safety profiles in mice, even after a prolonged period of administration. ASLAN003 is an agent targeting dihydroorotate dehydrogenase with potential in the treatment of acute myeloid leukemia. ASLAN003 is currently being evaluated in phase 2a clinical trial in acute myeloid leukemia patients[2].
Molecular Weight 356.32
Formula C19H14F2N2O3
CAS No. 1035688-66-4

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

DMSO: 120 mg/mL (336.78 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Marco L. Lolli, et al. Human Dihydroorotate Dehydrogenase (hDHODH) as a new target on Acute Myelogenous Leukemia (AML): Targeting Myeloid Differentiation using Potent and Innovative hDHODH Inhibitors. 23rd Swedish Conference on Macromolecular Structure and Function Tällberg, 14-17 June 2019 2. Jianbiao Zhou, et al. ASLAN003, a potent dihydroorotate dehydrogenase inhibitor for differentiation of acute myeloid leukemia. Haematologica. 2019 Nov7;haematol.2019.230482.

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