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APTSTAT3-9R acetate

Catalog No. TP2222L

APTSTAT3-9R acetate is a selective peptide binding STAT3 with antiproliferative and antitumor activity. APTSTAT3-9R acetate and inhibits STAT3 activation and downstream signaling by specifically blocking STAT3 phosphorylation.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

APTSTAT3-9R acetate, CAS N/A

Pack Size	Availability	Price/USD
1 mg	Inquiry	$ 227.00
5 mg	Inquiry	$ 677.00
10 mg	Inquiry	$ 997.00
25 mg	Inquiry	$ 1,827.00
50 mg	Inquiry	$ 2,742.00
100 mg	Inquiry	$ 4,113.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	APTSTAT3-9R acetate is a selective peptide binding STAT3 with antiproliferative and antitumor activity. APTSTAT3-9R acetate and inhibits STAT3 activation and downstream signaling by specifically blocking STAT3 phosphorylation.
In vitro	APTSTAT3-9R acetate (7.5, 15, and 30 μmol/L) significantly reduces STAT3–DNA-binding activity in a dose-dependent manner in human lung carcinoma cells (A549) but does not affect the level of AKT phosphorylation, indicating specificity of the aptide. APTSTAT3-9R acetate (30 μM) suppresses cell viability and proliferation of cancer cells and significantly suppresses colony formation. The IC50s are 10 to 20 μM in A549, B16F1, and HepG2 cells[1].
In vivo	In female BALB/c nude mice with A549 cells, APTSTAT3-9R acetate (8 mg/kg in 50 μL; intratumoral injection) suppresses tumor growth[1].

Molecular Weight	5007.56
Formula	C225H334N80O53

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Daejin Kim, et al. A Specific STAT3-binding Peptide Exerts Antiproliferative Effects and Antitumor Activity by Inhibiting STAT3 Phosphorylation and Signaling. Cancer Res. 2014 Apr 15;74(8):2144-51.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

APTSTAT3-9R acetate JAK/STAT signaling Stem Cells STAT APTSTAT39R acetate APTSTAT3 9R acetate APTSTAT3-9R Acetate inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.