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6,8-Diprenylnaringenin

Catalog No. TN3150 CAS 68236-11-3

6,8-Diprenylnaringenin is a natural product from hop Humulus lupulus. 6,8-Diprenylnaringenin is a breast cancer resistance protein(BCRP) inhibitor with some estrogenicity.

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6,8-Diprenylnaringenin, CAS 68236-11-3

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	6,8-Diprenylnaringenin is a natural product from hop Humulus lupulus. 6,8-Diprenylnaringenin is a breast cancer resistance protein(BCRP) inhibitor with some estrogenicity.
In vitro	6,8-Diprenylnaringenin inhibits ABCG2-mediated efflux of Mitoxantrone, and 3H-Methotrexate transport with an IC50 of 0.41 μM in HEK293 cells[1].

Molecular Weight	408.49
Formula	C25H28O5
CAS No.	68236-11-3

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Milligan SR, et al. The endocrine activities of 8-prenylnaringenin and related hop (Humulus lupulus L.) flavonoids. J Clin Endocrinol Metab. 2000 Dec;85(12):4912-5. 2. Tan KW, et al. Hop-derived prenylflavonoids are substrates and inhibitors of the efflux transporter breast cancer resistance protein (BCRP/ABCG2). Mol Nutr Food Res. 2014 Nov;58(11):2099-110.

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Keywords

6,8-Diprenylnaringenin 68236-11-3 其他 Others methotrexate transport cancer 6,8Diprenylnaringenin ABCG2 Breast cancer resistance protein efflux of mitoxantrone Lonchocarpol A Senegalensin Inhibitor cells estrogenicity 6,8 Diprenylnaringenin inhibit BCRP inhibitor

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