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5-Feruloylquinic acid

Catalog No. TN1296 CAS 40242-06-6

Synonyms: 5-FQA, 5-O-Feruloylquinic acid

5-O-Feruloylquinic acid is a potent Sirt1 agonist, it is a potential lead compound that can be further tested in drug development process for diseases associated with aging.

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5-Feruloylquinic acid, CAS 40242-06-6

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Purity: 98%

Biological Description

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Description

5-O-Feruloylquinic acid is a potent Sirt1 agonist, it is a potential lead compound that can be further tested in drug development process for diseases associated with aging.

In vitro

Traditional Chinese Medicine (TCM) compounds were employed for screening potent Sirt1 agonists, and molecular dynamics (MD) simulation was implemented to simulate ligand optimum docking poses and protein structure under dynamic conditions. TCM compounds such as (S)-tryptophan-betaxanthin, 5-O-Feruloylquinic acid, and RosA exhibited good binding affinity across different computational methods, and their drug-like potential were validated by MD simulation. Docking poses indicate that the carboxylic group of the three candidates generated H-bonds with residues in the protein chain from Ser441 to Lys444 and formed H-bond, π-cation interactions, or hydrophobic contacts with Phe297 and key active residue, His363. During MD, stable π-cation interactions with residues Phe273 or Arg274 were formed by (S)-tryptophan-betaxanthin and RosA[1].

Synonyms	5-FQA, 5-O-Feruloylquinic acid
Molecular Weight	368.34
Formula	C17H20O9
CAS No.	40242-06-6

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Investigation of silent information regulator 1 (Sirt1) agonists from Traditional Chinese Medicine.Journal of Biomolecular Structure and Dynamics, 2013, 31(11):1207-1218.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

5-Feruloylquinic acid 40242-06-6 Chromatin/Epigenetic DNA Damage/DNA Repair Proteases/Proteasome Tyrosinase Sirtuin 5-FQA 5 Feruloylquinic acid inhibit 5-O-Feruloylquinic acid 5Feruloylquinic acid Inhibitor inhibitor

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