Powder: -20°C for 3 years | In solvent: -80°C for 1 year
5-Chloro-2'-deoxyuridine (5-Chlorodeoxyuridine) is a thymine analog. It can be used to study the potential of hypochlorous acid damage to DNA and DNA precursors.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | In stock | $ 30.00 | |
50 mg | In stock | Inquiry | |
1 mL * 10 mM (in DMSO) | In stock | $ 43.00 |
Description | 5-Chloro-2'-deoxyuridine (5-Chlorodeoxyuridine) is a thymine analog. It can be used to study the potential of hypochlorous acid damage to DNA and DNA precursors. |
In vitro | The mammalian cells incorporate the analog into DNA when 5-Chloro-2’-deoxyuridine (ClDU) is placed into the tissue culture medium. It is observed that a 10 μM concentration of 5-Chloro-2’-deoxyuridine in the media does not alter cell division kinetics. Previously it has been shown that 5-Chloro-2’-deoxyuridine is metabolized and incorporated into DNA using antibodies that bind selectively to DNA containing halogenated bases. In this study, 5-Chloro-2’-deoxyuridine is more similar to BrdU in acting as a T analog. The toxicity of 5-Chloro-2’-deoxyuridine could in part be attributed to inhibition of thymidylate synthase [1]. |
Synonyms | 5-Chlorodeoxyuridine, CldU |
Molecular Weight | 262.65 |
Formula | C9H11ClN2O5 |
CAS No. | 50-90-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 125 mg/mL (475.92 mM)
You can also refer to dose conversion for different animals. More
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5-Chloro-2'-deoxyuridine 50-90-8 Others Inhibitor inhibit 5Chloro2'deoxyuridine 5-Chlorodeoxyuridine CldU 5 Chloro 2' deoxyuridine inhibitor