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4-Methylcatechol
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Catalog No. T4779Cas No. 452-86-8
Alias p-Methylcatechol, Homocatechol, 4-methylbenzene-1,2-diol, 3,4-Dihydroxytoluene
4-Methylcatechol (3,4-Dihydroxytoluene) is a metabolite of homoprotocatechuic acid. It is both a substrate and a suicide inhibitor of Catechol 2,3-dioxygenase. 4-Methylcatechol (3,4-Dihydroxytoluene) is known to induce the production of brain-derived neurotrophic factor (BDNF). Recent studies have suggested that a lack of brain-derived neurotrophic factor (BDNF) in the limbic system may cause neuropathic pain.
4-Methylcatechol
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Purity: 98.67%
Catalog No. T4779Alias p-Methylcatechol, Homocatechol, 4-methylbenzene-1,2-diol, 3,4-DihydroxytolueneCas No. 452-86-8
4-Methylcatechol (3,4-Dihydroxytoluene) is a metabolite of homoprotocatechuic acid. It is both a substrate and a suicide inhibitor of Catechol 2,3-dioxygenase. 4-Methylcatechol (3,4-Dihydroxytoluene) is known to induce the production of brain-derived neurotrophic factor (BDNF). Recent studies have suggested that a lack of brain-derived neurotrophic factor (BDNF) in the limbic system may cause neuropathic pain.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 500 mg | $35 | In Stock | - | |
| 1 g | $43 | In Stock | - | |
| 1 mL x 10 mM (in DMSO) | $29 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:98.67%
Appearance:Solid
Color:Red
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Product Introduction
4-Methylcatechol AI Summary
4-Methylcatechol exhibits strong growth inhibition activity against YT-nu and Don-6 cell lines at both 1.0 mM and 0.1 mM concentrations, with inhibition rates of 93.0% and 76.0%, respectively, at 1.0 mM. At 0.1 mM, the inhibition rates are 48.0% for YT-nu and 33.0% for Don-6 cell lines. It also displays cytotoxic activity against mouse L1210 cells with a log(1/ID50) value of 5.03. Furthermore, 4-Methylcatechol is an inhibitor of recombinant human IDO1 enzyme, showing 24.0% inhibition relative to the control using L-tryptophan as a substrate at a 1 mM concentration after 1 hour. In addition, it exhibits neuroprotective activity in mouse HT22 cells against t-BOOH-induced toxicity, with a 70.0% neuroprotective effect at 40 uM concentration. The compound has a LogD7.4 value of 1.37, indicating its distribution coefficient in an octan-1-ol/water solution at pH 7.4. It demonstrates antimicrobial activity against methicillin-resistant Staphylococcus aureus ATCC 33591 with an IC50 value of 72900.0 nM and against Staphylococcus aureus ATCC 29213 with an IC50 value of 147800.0 nM. Lastly, 4-Methylcatechol acts as an agonist at TRPA1 receptors with an EC50 value of 11700.0 nM, as shown by calcium imaging assays..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | 4-Methylcatechol (3,4-Dihydroxytoluene) is a metabolite of homoprotocatechuic acid. It is both a substrate and a suicide inhibitor of Catechol 2,3-dioxygenase. 4-Methylcatechol (3,4-Dihydroxytoluene) is known to induce the production of brain-derived neurotrophic factor (BDNF). Recent studies have suggested that a lack of brain-derived neurotrophic factor (BDNF) in the limbic system may cause neuropathic pain. |
| Synonyms | p-Methylcatechol, Homocatechol, 4-methylbenzene-1,2-diol, 3,4-Dihydroxytoluene |
| Molecular Weight | 124.14 |
| Formula | C7H8O2 |
| Cas No. | 452-86-8 |
| Smiles | CC1=CC(O)=C(O)C=C1 |
| Relative Density. | 1.129 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 250 mg/mL (2013.86 mM), Sonication is recommended.  Ethanol: Soluble H2O: Soluble | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (16.11 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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