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3-Isomangostin

Catalog No. T2S1635   CAS 19275-46-8

3-Isomangostin is an acetylcholinesterase selective inhibitor and a potent human aldose reductase inhibitor with an IC50 of 3.48 uM. 3-Isomangostin has free radical scavenging activity and inhibits MutT homolog 1 (MTH1) with an IC50 of 52 nM. It shows antiplasmodial activity with an IC50 values in the range of 4.71-11.40 uM. 3-Isomangostin can be used to develop anticancer agents as well.

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3-Isomangostin Chemical Structure
3-Isomangostin, CAS 19275-46-8
Pack Size Availability Price/USD Quantity
1 mg In stock $ 156.00
5 mg In stock $ 333.00
10 mg In stock $ 568.00
25 mg In stock $ 897.00
50 mg In stock $ 1,180.00
100 mg In stock $ 1,630.00
1 mL * 10 mM (in DMSO) In stock $ 388.00
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Purity: 99.76%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description 3-Isomangostin is an acetylcholinesterase selective inhibitor and a potent human aldose reductase inhibitor with an IC50 of 3.48 uM. 3-Isomangostin has free radical scavenging activity and inhibits MutT homolog 1 (MTH1) with an IC50 of 52 nM. It shows antiplasmodial activity with an IC50 values in the range of 4.71-11.40 uM. 3-Isomangostin can be used to develop anticancer agents as well.
Targets&IC50 MTH1:52 nM
In vitro Species of Garcinia have been used to combat malaria in traditional African and Asian medicines, including Ayurveda. In the current study, we have identified antiplasmodial benzophenone and xanthone compounds from edible Garcinia species by testing for in vitro inhibitory activity against Plasmodium falciparum. Whole fruits of Garcinia xanthochymus, G. mangostana, G. spicata, and G. livingstonei were extracted and tested for antiplasmodial activity. Garcinia xanthochymus was subjected to bioactivity-guided fractionation to identify active partitions. Purified benzophenones (1-9) and xanthones (10-18) were then screened in the plasmodial lactate dehydrogenase assay and tested for cytotoxicity against mammalian (Vero) cells. The benzophenones guttiferone E (4), isoxanthochymol (5), and guttiferone H (6), isolated from G. xanthochymus, and the xanthones α-mangostin (15), β-mangostin (16), and 3-Isomangostin (17), known from G. mangostana, showed antiplasmodial activity with an IC50 values in the range of 4.71-11.40 μM. Artemisinin and chloroquine were used as positive controls and exhibited an IC50 values in the range of 0.01-0.24 μM.
Source
Molecular Weight 410.46
Formula C24H26O6
CAS No. 19275-46-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 40mg/mL (97.45mM)

DMSO: 40mg/mL (97.45mM)

TargetMolReferences and Literature

1. In vitro antiplasmodial activity of benzophenones and xanthones from edible fruits of Garcinia species. Planta Med. 2014 Jun;80(8-9):676-81. 2. Health and Wellness Product from Mangosteen (Garcinia mangostana L.) Rind: Bioactive Potentials. International Journal of Biotechnology for Wellness Industries, 2015, 3(4):111-20.

Related compound libraries

This product is contained In the following compound libraries:
Tobacco Monomer Library Human Metabolite Library Inhibitor Library Bioactive Compound Library Anti-Cancer Active Compound Library Traditional Chinese Medicine Monomer Library Selected Plant-Sourced Compound Library NO PAINS Compound Library DNA Damage & Repair Compound Library Bioactive Compounds Library Max

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Keywords

3-Isomangostin 19275-46-8 DNA Damage/DNA Repair MTH1 DNA/RNA Synthesis inhibit 3Isomangostin 3 Isomangostin Inhibitor inhibitor

 

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