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(-)-Catechin
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Catalog No. T13597Cas No. 18829-70-4
Alias (-)-Cianidanol, (-)-Catechuic acid
(-)-Catechin ((-)-Cianidanol), an isomer of catechin, inhibits cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM.
(-)-Catechin
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Purity: 98.74%
Catalog No. T13597Alias (-)-Cianidanol, (-)-Catechuic acidCas No. 18829-70-4
(-)-Catechin ((-)-Cianidanol), an isomer of catechin, inhibits cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $40 | In Stock | In Stock | |
| 5 mg | $97 | In Stock | In Stock | |
| 10 mg | $189 | In Stock | In Stock | |
| 25 mg | $397 | In Stock | In Stock | |
| 50 mg | $589 | In Stock | In Stock | |
| 100 mg | $843 | In Stock | In Stock | |
| 500 mg | $1,730 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $97 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:98.74%
Appearance:Solid
Color:Yellow
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Product Introduction
(-)-Catechin AI Summary
(-)-Catechin is a multifaceted compound with various bioactivities and inhibitory properties. It inhibits human Beta-secretase 1 with an IC50 value of 30000.0 nM and shows antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum NF54 with an IC50 value greater than 150,000.0 nM. In opioid receptor assays, it acts as an antagonist at the human mu, delta, and kappa opioid receptors and demonstrates selective antagonism for the mu opioid receptor over the kappa receptor (Ki ratio 0.67) and for the delta receptor over the kappa receptor (Ki ratio 0.49). The compound also shows partial agonist activity, achieving an Emax of 18.0%.
Additionally, (-)-Catechin exhibits significant cytotoxic effects against human Raji cells, reducing cell viability below 80% across all tested concentrations. In inflammatory and oxidative stress assays, it inhibits the 12-O-tetradecanoylphorbol-13-acetate-induced EBV-early antigen activation in human Raji cells, with 100% inhibition at a 10:1 molar ratio relative to TPA.
Furthermore, (-)-Catechin shows bioactivity in inhibiting peroxidase (IC50 of 5300.0 nM) and cyclooxygenase activity of COX1 (IC50 of 30800.0 nM) in sheep seminal vesicle, along with modest inhibition of alpha-glucosidase (IC50 of 53,800.0 nM), SPI-1 T3SS in Salmonella typhimurium, and alpha-amylase activity with an inhibition percentage of 16.0%. It binds strongly to both rat and human pancreatic membrane proteins and serum albumin, indicating significant plasma protein binding.
The compound also demonstrates limited inhibitory activity against yeast G6PD, 6PGD, and IDH enzymes with IC50 values greater than 1000000.0 nM but exhibits 100.0-fold selectivity for inhibiting yeast G6PD over the G6PD-mediated NADPH production in mouse 3T3-L1 cells. It also exhibits antioxidant activity by inhibiting Fe2 ion-induced lipid peroxidation and scavenging hydroperoxyl at acidic pH.
Finally, (-)-Catechin shows reduced binding affinity for the Influenza A virus N-terminal GST-tagged polymerase acidic subunit with an IC50 value greater than 50000.0 nM and has negligible inhibitory effects on Trypanosoma cruzi trans-sialidase and human Neu2 activity, exhibiting IC50 values greater than 1000000.0 nM.
Overall, (-)-Catechin demonstrates a wide range of biological activities suggesting potential utility in multiple therapeutic areas, albeit with specific limitations in potency for certain targets..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | (-)-Catechin ((-)-Cianidanol), an isomer of catechin, inhibits cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM. |
| Targets&IC50 | COX-1:1.4 μM |
| Synonyms | (-)-Cianidanol, (-)-Catechuic acid |
| Molecular Weight | 290.27 |
| Formula | C15H14O6 |
| Cas No. | 18829-70-4 |
| Smiles | O[C@@H]1Cc2c(O)cc(O)cc2O[C@H]1c1ccc(O)c(O)c1 |
| Relative Density. | 1.593 g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 125 mg/mL (430.63 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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