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α-Lipoic Acid sodium

Name: α-Lipoic Acid sodium
Brand: TargetMol
SKU: T72429
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T72429Cas No. 2319-84-8

Alias Thioctic acid sodium, DL-α-Lipoic acid sodium, (±)-α-Lipoic acid sodium

α-Lipoic Acid sodium (Thioctic acid sodium) is an antioxidant and essential cofactor for mitochondrial enzyme complexes. It inhibits NF-κB-dependent HIV-1 replication, induces endoplasmic reticulum stress-mediated apoptosis in hepatocellular carcinoma cells, and modulates SREBP-1, FOXO1, and Nrf2 to improve high-fat diet-induced hepatic steatosis.

α-Lipoic Acid sodium

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Purity: 99.68%

Catalog No. T72429Alias Thioctic acid sodium, DL-α-Lipoic acid sodium, (±)-α-Lipoic acid sodiumCas No. 2319-84-8

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 g	$40	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.68%

Appearance:Solid

Color:Yellow

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	α-Lipoic Acid sodium (Thioctic acid sodium) is an antioxidant and essential cofactor for mitochondrial enzyme complexes. It inhibits NF-κB-dependent HIV-1 replication, induces endoplasmic reticulum stress-mediated apoptosis in hepatocellular carcinoma cells, and modulates SREBP-1, FOXO1, and Nrf2 to improve high-fat diet-induced hepatic steatosis.
In vitro	α-Lipoic Acid sodium (250, 500, and 1000 μM) significantly increased the NAD⁺/NADH ratio in HepG2 cells; α-Lipoic Acid (50, 125, 250, and 500 μM) enhanced SIRT1 activity in HepG2 cells; α-Lipoic Acid (50, 125, 250, 500, and 100 μM) promoted the phosphorylation levels of AMPK and ACC in HepG2 cells in a dose-dependent manner [1].
In vivo	α-Lipoic Acid sodium (100 mg/kg or 200 mg/kg) significantly reduces visceral fat content in mice on a long-term high-fat diet, while also suppressing appetite and causing a notable decrease in body weight [1].
Synonyms	Thioctic acid sodium, DL-α-Lipoic acid sodium, (±)-α-Lipoic acid sodium

Chemical Properties

Molecular Weight	228.31
Formula	C₈H₁₃NaO₂S₂
Cas No.	2319-84-8
Smiles	O=C(CCCCC1SSCC1)[O-].[Na+]

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 28 mg/mL (122.64 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	4.3800 mL	21.9000 mL	43.8001 mL	219.0005 mL
5 mM	0.8760 mL	4.3800 mL	8.7600 mL	43.8001 mL
10 mM	0.4380 mL	2.1900 mL	4.3800 mL	21.9000 mL
20 mM	0.2190 mL	1.0950 mL	2.1900 mL	10.9500 mL
50 mM	0.0876 mL	0.4380 mL	0.8760 mL	4.3800 mL
100 mM	0.0438 mL	0.2190 mL	0.4380 mL	2.1900 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc