Powder: -20°C for 3 years | In solvent: -80°C for 1 year
(-)-Securinine (Securinine) is plant-derived alkaloid and also a GABAA receptor antagonist.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 50.00 | |
10 mg | In stock | $ 83.00 | |
25 mg | In stock | $ 173.00 | |
50 mg | In stock | $ 254.00 | |
100 mg | In stock | $ 381.00 |
Description | (-)-Securinine (Securinine) is plant-derived alkaloid and also a GABAA receptor antagonist. |
In vitro | (-)-Securinine significantly inhibits HeLa cells growth with IC50 values of 7.02±0.52 μg/mL (32.3 μM). (-)-Securinine induces apoptosis in a dose-dependent manner in the tested cells, increases the percentage of ROS positive cells and depolarized cells as well as stimulates the activity of ERK1/2, caspase-9 and -3/7. (-)-Securinine also induces cell cycle arrest in S phase. Real-time PCR analysis shows high expression of tumor necrosis factor receptor superfamily (TNFRSF) genes in the cells stimulated with (-)-Securinine. |
In vivo | In the tumor model, treatment with (-)-Securinine markedly inhibits tumor growth, suggesting its potential as an Acute Myeloid Leukemia (AML) treatment. Mice treated with (-)-Securinine (n=5 mice, bilateral tumors) show tumors that are, on average, over 75% smaller than those in vehicle-treated mice at the conclusion of the study. |
Source |
Synonyms | Securinine |
Molecular Weight | 217.26 |
Formula | C13H15NO2 |
CAS No. | 5610-40-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 2 mg/mL (9.21 mM)
You can also refer to dose conversion for different animals. More
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(-)-Securinine 5610-40-2 Membrane transporter/Ion channel Neuroscience GABA Receptor ()Securinine inhibit Inhibitor Securinine Gamma-aminobutyric acid Receptor ( ) Securinine γ-Aminobutyric acid Receptor inhibitor