Powder: -20°C for 3 years | In solvent: -80°C for 1 year
(±)-CPSI-1306 (2-(3-(2,4-Difluorophenyl)-4,5-dihydroisoxazol-5-yl)-1-morpholinoethan-1-one) is a macrophage migration inhibitory factor (MIF) antagonist and can be used in studies about non-insulin-dependent diabetes mellitus (NIDDM) and the prevention of the deleterious cutaneous effects of acute and chronic UVB exposure.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
10 mg | In stock | $ 45.00 | |
25 mg | In stock | $ 82.00 | |
50 mg | In stock | $ 148.00 | |
100 mg | In stock | $ 268.00 | |
200 mg | In stock | $ 365.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 50.00 |
Description | (±)-CPSI-1306 (2-(3-(2,4-Difluorophenyl)-4,5-dihydroisoxazol-5-yl)-1-morpholinoethan-1-one) is a macrophage migration inhibitory factor (MIF) antagonist and can be used in studies about non-insulin-dependent diabetes mellitus (NIDDM) and the prevention of the deleterious cutaneous effects of acute and chronic UVB exposure. |
In vivo | In mice, (±)-CPSI-1306 decreases their blood glucose levels and can be effective in treating non-insulin-dependent diabetes mellitus (NIDDM) as characterized by high serum levels of glucose and inflammatory cytokine[1]. (±)-CPSI-1306-induced keratinocyte apoptosis is appreciated 30 minutes after a single UVB exposure. (±)-CPSI-1306-treated mice show a significant increase in expression of cleaved caspase-3 at 6, 24, and 48 hours following UVB exposure. (±)-CPSI-1306 reduces acute UVB-induced keratinocyte DNA damage and UVB-induced acute inflammation[2]. |
Synonyms | cpsi-1306, 2-(3-(2,4-Difluorophenyl)-4,5-dihydroisoxazol-5-yl)-1-morpholinoethan-1-one |
Molecular Weight | 310.3 |
Formula | C15H16F2N2O3 |
CAS No. | 1309793-47-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 5 mg/mL (16.1 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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(±)-CPSI-1306 1309793-47-2 Others cpsi-1306 CPSI-1306 CPSI1306 2-(3-(2,4-Difluorophenyl)-4,5-dihydroisoxazol-5-yl)-1-morpholinoethan-1-one CPSI 1306 inhibitor inhibit