Powder: -20°C for 3 years | In solvent: -80°C for 1 year
(+)-DHMEQ is an antioxidant transcription factor Nrf2 activator. (+)-DHMEQ is the enantiomer of (-)-DHMEQ.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | 5 days | $ 134.00 | |
25 mg | 6-8 weeks | $ 689.00 | |
50 mg | 6-8 weeks | $ 896.00 | |
100 mg | 6-8 weeks | $ 1,350.00 |
Description | (+)-DHMEQ is an antioxidant transcription factor Nrf2 activator. (+)-DHMEQ is the enantiomer of (-)-DHMEQ. |
In vitro | (+)-DHMEQ activates Nrf2, a transcription factor that can induce the expression of various antioxidant enzymes. (+)-DHMEQ activates Nrf2 in promoter reporter gene analysis. (+)-DHMEQ also increases the expression of target antioxidant proteins in nerve cell lines and eliminates reactive oxygen species (ROS)-induced cell death. ROS generating 6-hydroxydopamine hydrochloride (6-OHDA) induces the death of SK-N-SH cells, and (+)-DHMEQ decreases the cytotoxic effect of 6-OHDA, whereas its effect is weaker in Nrf2-knockdown cells prepared with siRNA. Thus, enhancement of the neural cell viability by (+)-DHMEQ is due to the activation of Nrf2. |
Synonyms | (1R,2R,6R)-Dehydroxymethylepoxyquinomicin, (1R,2R,6R)-DHMEQ |
Molecular Weight | 261.23 |
Formula | C13H11NO5 |
CAS No. | 287194-41-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (382.80 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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(+)-DHMEQ 287194-41-6 Others (+) DHMEQ Dehydroxymethylepoxyquinomicin (1R,2R,6R)-Dehydroxymethylepoxyquinomicin (+)DHMEQ DHMEQ (1R,2R,6R)-DHMEQ inhibitor inhibit