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Search Results for " midbrain "

8

Compounds

Cat No. Product Name Synonyms Targets
T28368 PF-04859989 HCl PF 04859989,PF04859989,PF-04859989HCl,PF-04859989 Others
PF-04859989 HCl is a brain-penetrable irreversible inhibitor of kynurenine amino transferase II (KAT II), the enzyme responsible for most of the brain synthesis of kynurenic acid. PF-04859989 HCl has been implicated in s...
T4297 Flibanserin BIMT-17BS,Girosa,BIMT-17 Dopamine Receptor , 5-HT Receptor
Flibanserin (Girosa) is a serotonergic antidepressant used to treat hypoactive sexual desire disorder. Flibanserin has been associated with a low rate of minor serum aminotransferase elevations during treatment but has n...
T27936 LY262691 LY 262691,LY-262691
LY262691, a selective CCKB antagonist, decreases midbrain dopamine unit activity.
T38202 PAQ
PAQ is a neuroprotective agent. It protects dopaminergic neurons from cell death without inhibiting glial cell proliferation in a rat midbrain culture model of Parkinson's disease when used at a concentration of 10 μM. P...
T73272 VU6019650
VU6019650 is a potent and selective orthosteric antagonist of M5 mAChR ( IC 50 =36 nM), can be used for opioid use disorder (OUD) relief. VU6019650 can cross blood brain barrier, potentially modulates the mesolimbic dopa...
T62706 RTI-7470-44
RTI-7470-44 is a potent and selective human trace amine-associated receptor 1 (hTAAR1) antagonist (IC50: 8.4 nM) that crosses the blood-brain barrier. RTI-7470-44 increases the spontaneous firing rate of dopaminergic neu...
T70818 TC-2153
TC-2153 is a selective inhibitor of striatal-enriched protein tyrosine phosphatase (STEP), exhibiting psychotropic activity and low acute toxicity. This compound not only enhances the expression of brain-derived neurotro...
T76404 [Glp5,(Me)Phe8,Sar9] Substance P (5-11)
[Glp5,(Me)Phe8,Sar9] Substance P (5-11) (DiMe-C7) is an analogue of Substance P that acts on the neurokinin 1 receptor (NK1R) in rat brain, similarly to Substance P but with a significantly extended duration of action. T...
TargetMol