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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T28368 | PF-04859989 HCl | PF 04859989,PF04859989,PF-04859989HCl,PF-04859989 | Others |
PF-04859989 HCl is a brain-penetrable irreversible inhibitor of kynurenine amino transferase II (KAT II), the enzyme responsible for most of the brain synthesis of kynurenic acid. PF-04859989 HCl has been implicated in s... | |||
T4297 | Flibanserin | BIMT-17BS,Girosa,BIMT-17 | Dopamine Receptor , 5-HT Receptor |
Flibanserin (Girosa) is a serotonergic antidepressant used to treat hypoactive sexual desire disorder. Flibanserin has been associated with a low rate of minor serum aminotransferase elevations during treatment but has n... | |||
T27936 | LY262691 | LY 262691,LY-262691 | |
LY262691, a selective CCKB antagonist, decreases midbrain dopamine unit activity. | |||
T38202 | PAQ | ||
PAQ is a neuroprotective agent. It protects dopaminergic neurons from cell death without inhibiting glial cell proliferation in a rat midbrain culture model of Parkinson's disease when used at a concentration of 10 μM. P... | |||
T73272 | VU6019650 | ||
VU6019650 is a potent and selective orthosteric antagonist of M5 mAChR ( IC 50 =36 nM), can be used for opioid use disorder (OUD) relief. VU6019650 can cross blood brain barrier, potentially modulates the mesolimbic dopa... | |||
T62706 | RTI-7470-44 | ||
RTI-7470-44 is a potent and selective human trace amine-associated receptor 1 (hTAAR1) antagonist (IC50: 8.4 nM) that crosses the blood-brain barrier. RTI-7470-44 increases the spontaneous firing rate of dopaminergic neu... | |||
T70818 | TC-2153 | ||
TC-2153 is a selective inhibitor of striatal-enriched protein tyrosine phosphatase (STEP), exhibiting psychotropic activity and low acute toxicity. This compound not only enhances the expression of brain-derived neurotro... | |||
T76404 | [Glp5,(Me)Phe8,Sar9] Substance P (5-11) | ||
[Glp5,(Me)Phe8,Sar9] Substance P (5-11) (DiMe-C7) is an analogue of Substance P that acts on the neurokinin 1 receptor (NK1R) in rat brain, similarly to Substance P but with a significantly extended duration of action. T... |