19
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T38889 | Thailanstatin A | ||
Thailanstatin A is an ultra-potent inhibitor of eukaryotic RNA splicing (IC50 =650 nM). Thailanstatin A inhibits multiple cancer cell lines via non-covalent binding to the SF3b subunit of the U2 snRNA subcomplex of the s... | |||
T11917 | Lys-SMCC-DM1 | Lys-Nε-MCC-DM1 | Microtubule Associated |
DM1 is a tubulin inhibitor. Lys-SMCC-DM1 (Lys-Nε-MCC-DM1) is the active metabolite of DM1. | |||
T18730 | Sulfo-SPDB-DM4 | Others | |
Sulfo-SPDB-DM4 is a drug-linker conjugate designed for antibody-drug conjugates (ADCs) that employs the maytansine-based payload (DM4, an antitubulin agent) connected through the sulfo-SPDB linker. | |||
T18701 | SPDB-DM4 | Others | |
SPDB-DM4 is a drug-linker conjugate designed for antibody-drug conjugate (ADC) applications, employing the maytansine-based payload DM4 (a tubulin inhibitor) connected through a SPDB linker. This compound demonstrates si... | |||
T39373 | PNU-EDA-Gly5 | PNU-EDA-Gly5 | |
PNU-EDA-Gly5 is a DNA topoisomerase I inhibitor-based oligo-glycine linker-payload used for the synthesis of antibody-drug conjugates (ADCs). It consists of the DNA topoisomerase I inhibitor PNU-159682 and the linker EDA... | |||
T79206 | MC-EVCit-PAB-MMAE | ||
MC-EVCit-PAB-MMAE (Linker-Payload 11), a conjugate utilized in antibody-drug conjugates (ADCs), comprises the MC-EVCit-PAB linker attached to the powerful tubulin polymerization inhibitor MMAE [1]. | |||
T18477 | NAMPT inhibitor-linker 1 | Others | |
NAMPT inhibitor-linker 1, a drug-linker conjugate for ADC, integrates an NAMPT inhibitor (as a payload) with a linker. In the formulation of ADC-3, it pairs with an anti-c-Kit monoclonal antibody, demonstrating strong ef... | |||
T17789 | DBCO-(PEG2-VC-PAB-MMAE)2 | Others | |
DBCO-(PEG2-VC-PAB-MMAE)2 consists of Monomethyl auristatin E (MMAE), a toxin payload in antibody-drug conjugate [1], conjugated to the cleavable linker DBCO-(PEG2-VC-PAB)2. MMAE, a potent tubulin inhibitor, serves as the... | |||
T18478 | NAMPT inhibitor-linker 2 | Others | |
NAMPT inhibitor-linker 2, a drug-linker conjugate for antibody-drug conjugates (ADCs), comprises an NAMPT inhibitor payload and a linker. When combined with an anti-c-Kit monoclonal antibody to form ADC-4, it demonstrate... | |||
T17817 | DBCO-(PEG)3-VC-PAB-MMAE | Others | |
DBCO-(PEG)3-VC-PAB-MMAE is a chemical compound where monomethyl auristatin E (MMAE), a potent tubulin inhibitor acting as a toxin payload in antibody-drug conjugates, is conjugated to a DBCO-(PEG)3-vc-PAB linker. | |||
T18303 | Mal-Phe-C4-VC-PAB-MMAE | Others | |
Mal-Phe-C4-VC-PAB-MMAE is a chemical compound resulting from the conjugation of monomethyl auristatin E (MMAE), a potent tubulin inhibitor serving as a toxin payload in antibody-drug conjugates, with a Mal-Phe-C4-VC-PAB ... | |||
T17799 | DBCO-PEG4-SS-TCO | Others | |
DBCO-PEG4-SS-TCO is a cleavable 4-unit polyethylene glycol (PEG) linker essential for the synthesis of antibody-drug conjugates (ADCs)[1]. It plays a crucial role in connecting the drug payload to the antibody, enabling ... | |||
T39458 | DGN549-C | DGN549-C | |
DGN549-C is a novel compound featuring a cleavable ADC (antibody-drug conjugate) linker composed of valine-alanine (va) and a PBD (pyrrolobenzodiazepine) dimer. This compound possesses a unique DNA-alkylating cytotoxic p... | |||
T15872 | M-PEG4-Br | Others | |
m-PEG4-Br is a cleavable ADC linker used in the synthesis of antibody-drug conjugate (ADC) for Trastuzumab. m-PEG4-Br is placed distally from the monomethyl auristatin E (MMAE) payload to yield an ADC with altered hydrop... | |||
T77910 | Patritumab deruxtecan | U3-1287,HER3-DXd | |
Patritumab deruxtecan (HER3-DXd), an antibody-drug conjugate (ADC), comprises a fully human anti-HER3 IgG1 monoclonal antibody, Patritumab, linked to a topoisomerase I inhibitor payload through a tetrapeptide-based cleav... | |||
T18522 | PC Mal-NHS carbonate ester | Others | |
PC Mal-NHS carbonate ester is a cleavable linker specifically designed for the synthesis of antibody-drug conjugates (ADCs)[1]. This chemical compound plays a crucial role in facilitating the conjugation of drugs to anti... | |||
T38503 | (2-pyridyldithio)-PEG1-hydrazine | (2-pyridyldithio)-PEG1-hydrazine | |
(2-Pyridyldithio)-PEG1-hydrazine is a one-unit cleavable polyethylene glycol (PEG) linker specifically designed for the synthesis of antibody-drug conjugates (ADCs). This linker offers the advantage of controlled release... | |||
T75134 | MC-GGFG-AM-(10Me-11F-Camptothecin) | ||
MC-GGFG-AM-(10Me-11F-Camptothecin) acts as a linker-payload conjugate in the synthesis of ZW251, an antibody-drug conjugate (ADC) designed to target human GPC3. This ADC comprises a humanized IgG1 antibody attached to ZD... | |||
T82021 | Izeltabart | IMGC-936 | |
Izeltabart (IMGC-936) is a Maytansinoid-based Antibody-Drug Conjugate (ADC) that specifically targets ADAM9. It consists of a high-affinity humanized antibody conjugated site-specifically to DM21-C, a linker-payload that... |