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Search Results for " cancer-initiating "

6

Compounds

Cat No. Product Name Synonyms Targets
T2345 PTC-209 PTC209,PTC 209 BMI-1 , Autophagy
PTC-209 is a potent and selective BMI-1 inhibitor.
T6178 PTC-209 hydrobromide PTC-209 HBr BMI-1 , Autophagy
PTC-209 hydrobromide (PTC-209 HBr) is the hydrobromide salt of PTC-209, which is a potent and selective BMI-1 inhibitor with IC50 of 0.5 μM, and results in irreversible reduction of cancer-initiating cells (CICs).
T38637 Roy-Bz
Roy-Bz is a potent and selective activator of protein kinase C delta (PKCδ). It effectively inhibits proliferation in colon cancer cells by initiating a mitochondrial apoptotic pathway that relies on PKCδ and involves th...
T36485 Becatecarin
Becatecarin is a water-soluble, diethylaminoethyl analog of the antineoplastic antibiotic rebeccamycin. It intercalates into DNA, stabilizing the DNA-topoisomerase complex. This results in the potent catalytic inhibition...
T35940 Darinaparsin Dimethylarsinic glutathione,Darinaparsin
Darinaparsin is a dimethylated arsenic linked to glutathione. It is cytotoxic to DU145, LNCaP, and PC3 prostate cancer cells (IC50s = 5-10 µM) and patient-derived primary prostate cancer cells (IC50s = 2.5-20 µM)...
T79558 Fac-[Re(CO)3(L3)(H2O)][NO3]
Fac-[Re(CO)3(L3)(H2O)][NO3] (Compound 3), a rhenium(I) tricarbonyl aqua complex, acts as an anticancer agent through the induction of mitochondrial dysfunction. It exhibits cytotoxicity against prostate cancer cells, dem...
TargetMol